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Hypoxia regulates GR function through multiple mechanisms involving microRNAs 103 and 107
Glucocorticoids (Gcs) potently inhibit inflammation, and regulate liver energy metabolism, often acting in a hypoxic environment. We now show hypoxic conditions open a specific GR cistrome, and prevent access of GR to part of the normoxic GR cistrome. Motif analysis identified enrichment of KLF4 bin...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
North Holland Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646191/ https://www.ncbi.nlm.nih.gov/pubmed/32871225 http://dx.doi.org/10.1016/j.mce.2020.111007 |