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Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses
BACKGROUND: Despite hepatotoxic effects, imidocarb dipropionate is the drug of choice for treatment of equine piroplasmosis. It is important, therefore, to identify adjuvant therapies that may improve the safety of imidocarb dipropionate by reducing the risk of liver damage during its use. The aim o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646365/ https://www.ncbi.nlm.nih.gov/pubmed/33178437 http://dx.doi.org/10.1136/vetreco-2020-000416 |
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author | Jaramillo, Fernando Mosquera Piñeros, Diego Darley Velasquez Corrêa, Rodrigo Romero Pogliani, Fabio Celidonio Cogliati, Bruno Baccarin, Raquel Yvonne Arantes |
author_facet | Jaramillo, Fernando Mosquera Piñeros, Diego Darley Velasquez Corrêa, Rodrigo Romero Pogliani, Fabio Celidonio Cogliati, Bruno Baccarin, Raquel Yvonne Arantes |
author_sort | Jaramillo, Fernando Mosquera |
collection | PubMed |
description | BACKGROUND: Despite hepatotoxic effects, imidocarb dipropionate is the drug of choice for treatment of equine piroplasmosis. It is important, therefore, to identify adjuvant therapies that may improve the safety of imidocarb dipropionate by reducing the risk of liver damage during its use. The aim of the present study was to evaluate the hepatoprotective and hepatoregulatory effects of treatment with Cynara scolymus and Silybum marianum during administration of imidocarb dipropionate. METHODS: Ten healthy horses, seroconverted to Theileria equi by C-ELISA, were treated with 5 mg/kg/day of imidocarb dipropionate for three consecutive days. The study population was divided into two groups. The control group did not receive any complementary treatments. The treated group received a daily oral supplement containing C scolymus and S marianum for 30 days. Physical, haematological and histological examinations of hepatic fragments were performed. RESULTS: All haematological values remained within normal range for the study population. Histological analysis revealed that treated group animals had 62 per cent less lobular inflammation, 55 per cent less pigment accumulation, 65 per cent less steatosis and 57 per cent less portal inflammation than control group animals, with an equivalent percentage of hydropic degeneration. CONCLUSION: C scolymus and S marianum supplements resulted in beneficial hepatoprotective effects in horses treated with imidocarb dipropionate. |
format | Online Article Text |
id | pubmed-7646365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-76463652020-11-10 Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses Jaramillo, Fernando Mosquera Piñeros, Diego Darley Velasquez Corrêa, Rodrigo Romero Pogliani, Fabio Celidonio Cogliati, Bruno Baccarin, Raquel Yvonne Arantes Vet Rec Open Horses and Other Equids BACKGROUND: Despite hepatotoxic effects, imidocarb dipropionate is the drug of choice for treatment of equine piroplasmosis. It is important, therefore, to identify adjuvant therapies that may improve the safety of imidocarb dipropionate by reducing the risk of liver damage during its use. The aim of the present study was to evaluate the hepatoprotective and hepatoregulatory effects of treatment with Cynara scolymus and Silybum marianum during administration of imidocarb dipropionate. METHODS: Ten healthy horses, seroconverted to Theileria equi by C-ELISA, were treated with 5 mg/kg/day of imidocarb dipropionate for three consecutive days. The study population was divided into two groups. The control group did not receive any complementary treatments. The treated group received a daily oral supplement containing C scolymus and S marianum for 30 days. Physical, haematological and histological examinations of hepatic fragments were performed. RESULTS: All haematological values remained within normal range for the study population. Histological analysis revealed that treated group animals had 62 per cent less lobular inflammation, 55 per cent less pigment accumulation, 65 per cent less steatosis and 57 per cent less portal inflammation than control group animals, with an equivalent percentage of hydropic degeneration. CONCLUSION: C scolymus and S marianum supplements resulted in beneficial hepatoprotective effects in horses treated with imidocarb dipropionate. BMJ Publishing Group 2020-11-05 /pmc/articles/PMC7646365/ /pubmed/33178437 http://dx.doi.org/10.1136/vetreco-2020-000416 Text en © British Veterinary Association 2020. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, an indication of whether changes were made, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Horses and Other Equids Jaramillo, Fernando Mosquera Piñeros, Diego Darley Velasquez Corrêa, Rodrigo Romero Pogliani, Fabio Celidonio Cogliati, Bruno Baccarin, Raquel Yvonne Arantes Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
title | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
title_full | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
title_fullStr | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
title_full_unstemmed | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
title_short | Efficacy of oral Cynara scolymus and Silybum marianum on toxicity of imidocarb dipropionate in horses |
title_sort | efficacy of oral cynara scolymus and silybum marianum on toxicity of imidocarb dipropionate in horses |
topic | Horses and Other Equids |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646365/ https://www.ncbi.nlm.nih.gov/pubmed/33178437 http://dx.doi.org/10.1136/vetreco-2020-000416 |
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