Cargando…

Anti-MAdCAM-1-Conjugated Nanocarriers Delivering Quantum Dots Enable Specific Imaging of Inflammatory Bowel Disease

PURPOSE: Assessment of inflammatory bowel disease (IBD) currently relies on aspecific clinical signs of bowel inflammation. Specific imaging of the diseased bowel regions is still lacking. Here, we investigate mucosal addressin cell adhesion molecule 1 (MAdCAM-1) as a reliable and specific endotheli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Truffi, Marta, Sevieri, Marta, Morelli, Lucia, Monieri, Matteo, Mazzucchelli, Serena, Sorrentino, Luca, Allevi, Raffaele, Bonizzi, Arianna, Zerbi, Pietro, Marchini, Beatrice, Longhi, Erika, Sampietro, Gianluca Matteo, Colombo, Francesco, Prosperi, Davide, Colombo, Miriam, Corsi, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646444/ https://www.ncbi.nlm.nih.gov/pubmed/33173291 http://dx.doi.org/10.2147/IJN.S264513

Ejemplares similares

Co-administration of H-ferritin-doxorubicin and Trastuzumab in neoadjuvant setting improves efficacy and prevents cardiotoxicity in HER2 + murine breast cancer model
por: Andreata, F., et al.
Publicado: (2020)

Multivalent exposure of trastuzumab on iron oxide nanoparticles improves antitumor potential and reduces resistance in HER2-positive breast cancer cells
por: Truffi, Marta, et al.
Publicado: (2018)

Combined Method to Remove Endotoxins from Protein Nanocages for Drug Delivery Applications: The Case of Human Ferritin
por: Silva, Filippo, et al.
Publicado: (2021)

Tumor Accumulation and Off-Target Biodistribution of an Indocyanine-Green Fluorescent Nanotracer: An Ex Vivo Study on an Orthotopic Murine Model of Breast Cancer
por: Sevieri, Marta, et al.
Publicado: (2021)

Everolimus Nanoformulation in Biological Nanoparticles Increases Drug Responsiveness in Resistant and Low-Responsive Breast Cancer Cell Lines
por: Bonizzi, Arianna, et al.
Publicado: (2019)

Selective Targeting of Cancer-Associated Fibroblasts by Engineered H-Ferritin Nanocages Loaded with Navitoclax
por: Sitia, Leopoldo, et al.
Publicado: (2021)

Indocyanine Green Nanoparticles: Are They Compelling for Cancer Treatment?
por: Sevieri, Marta, et al.
Publicado: (2020)

Protein-Based Nanoparticles for the Imaging and Treatment of Solid Tumors: The Case of Ferritin Nanocages, a Narrative Review
por: Mainini, Francesco, et al.
Publicado: (2021)

Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy
por: Truffi, Marta, et al.
Publicado: (2019)

Novel Bioengineering Strategies to Improve Bioavailability and In Vivo Circulation of H-Ferritin Nanocages by Surface Functionalization
por: Sevieri, Marta, et al.
Publicado: (2023)

Development of Tumor-Targeted Indocyanine Green-Loaded Ferritin Nanoparticles for Intraoperative Detection of Cancers
por: Sitia, Leopoldo, et al.
Publicado: (2020)

In Vitro Immunoreactivity Evaluation of H-Ferritin-Based Nanodrugs
por: Sitia, Leopoldo, et al.
Publicado: (2023)

MAdCAM costimulation through Integrin-α(4)β(7) promotes HIV replication
por: Nawaz, Fatima, et al.
Publicado: (2018)

Development of Mucosal PNAd(+) and MAdCAM-1(+) Venules during Disease Course in Ulcerative Colitis
por: Roosenboom, Britt, et al.
Publicado: (2020)

Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance
por: Fidelle, Marine, et al.
Publicado: (2023)

The Force-Dependent Mechanism of an Integrin α4β7–MAdCAM-1 Interaction
por: Su, Youmin, et al.
Publicado: (2023)

Ultrastructural analysis of breast cancer patient-derived organoids
por: Signati, Lorena, et al.
Publicado: (2021)

TNF-α induced endothelial MAdCAM-1 expression is regulated by exogenous, not endogenous nitric oxide
por: Oshima, Tadayuki, et al.
Publicado: (2001)

MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis
por: Kuhbandner, Kristina, et al.
Publicado: (2019)

Establishment and Morphological Characterization of Patient-Derived Organoids from Breast Cancer
por: Mazzucchelli, S., et al.
Publicado: (2019)

Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kB.
por: Sasaki, Makoto, et al.
Publicado: (2002)

Bile Acids Modulate Colonic MAdCAM-1 Expression in a Murine Model of Combined Cholestasis and Colitis
por: Gao, Rachel Y., et al.
Publicado: (2020)

Circulating MAdCAM-1 and ITGB7 in Patients with Plaque Psoriasis and Eruptive Lichen Planus—Preliminary Data
por: Baran, Anna, et al.
Publicado: (2021)

Nanometronomic treatment of 4T1 breast cancer with nanocaged doxorubicin prevents drug resistance and circumvents cardiotoxicity
por: Mazzucchelli, Serena, et al.
Publicado: (2016)

Involvement of oxidative stress and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in inflammatory bowel disease
por: Tanida, Satoshi, et al.
Publicado: (2011)

Phase II evaluation of anti-MAdCAM antibody PF-00547659 in the treatment of Crohn’s disease: report of the OPERA study
por: Sandborn, William J, et al.
Publicado: (2018)

Vedolizumab blocks α4β7 integrin-mediated T cell adhesion to MAdCAM-1 in microscopic colitis
por: Besendorf, Laura, et al.
Publicado: (2022)

Circulating Fibroblast Activation Protein as Potential Biomarker in Patients With Inflammatory Bowel Disease
por: Corsi, Fabio, et al.
Publicado: (2021)

Anti-MAdCAM-1 antibody (PF-00547659) for active refractory Crohn’s disease in Japanese and Korean patients: the OPERA study
por: Saruta, Masayuki, et al.
Publicado: (2020)

Bisdemethoxycurcumin (BDC)-Loaded H-Ferritin-Nanocages Mediate the Regulation of Inflammation in Alzheimer’s Disease Patients
por: Gagliardi, Stella, et al.
Publicado: (2022)

Anti-MAdCAM Antibody Increases ß7+ T Cells and CCR9 Gene Expression in the Peripheral Blood of Patients With Crohn’s Disease
por: Hassan-Zahraee, Mina, et al.
Publicado: (2018)

α4β7 integrin-dependent adhesion of T cells to MAdCAM-1 is blocked by vedolizumab in patients with chronic refractory pouchitis
por: Melde, Michaela, et al.
Publicado: (2021)

HER-2-Targeted Nanoparticles for Breast Cancer Diagnosis and Treatment
por: Sitia, Leopoldo, et al.
Publicado: (2022)

MAdCAM-1/α4β7 Integrin-Mediated Lymphocyte/Endothelium Interactions Exacerbate Acute Immune-Mediated Hepatitis in Mice
por: Schippers, Angela, et al.
Publicado: (2020)

Force-Regulated Calcium Signaling of Lymphoid Cell RPMI 8226 Mediated by Integrin α(4)β(7)/MAdCAM-1 in Flow
por: Sun, Dongshan, et al.
Publicado: (2023)

Transfection of IL-10 expression vectors into endothelial cultures attenuates α4β7-dependent lymphocyte adhesion mediated by MAdCAM-1
por: Sasaki, Makoto, et al.
Publicado: (2003)

The Sphingosine-1-Phosphate (S1P) Lysophospholipid Receptor S1P(3) Regulates MAdCAM-1(+) Endothelial Cells in Splenic Marginal Sinus Organization
por: Girkontaite, Irute, et al.
Publicado: (2004)

Differential Effects of the Absence of Nkx2-3 and MAdCAM-1 on the Distribution of Intestinal Type 3 Innate Lymphoid Cells and Postnatal SILT Formation in Mice
por: Vojkovics, Dóra, et al.
Publicado: (2019)

Baseline levels of dynamic CD4(+) T cell adhesion to MAdCAM-1 correlate with clinical response to vedolizumab treatment in ulcerative colitis: a cohort study
por: Allner, Clarissa, et al.
Publicado: (2020)

Antibody secreting cells are critically dependent on integrin α4β7/MAdCAM-1 for intestinal recruitment and control of the microbiota during chronic colitis
por: Tyler, Christopher J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_fl08oq3i6b5g4fnv98arirhs74