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Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer
BACKGROUND: APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C. Only a few APOBEC-associated driver hotspot mutat...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646471/ https://www.ncbi.nlm.nih.gov/pubmed/32988402 http://dx.doi.org/10.1186/s13073-020-00781-y |