Cargando…

Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo

Antibody-based delivery of bioactive molecules represents a promising strategy for the improvement of cancer immunotherapy. Here, we describe the generation and characterization of R6N, a novel fully human antibody specific to the alternatively spliced domain D of Tenascin C, which is highly express...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nadal, Lisa, Corbellari, Riccardo, Villa, Alessandra, Weiss, Tobias, Weller, Michael, Neri, Dario, De Luca, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646483/ https://www.ncbi.nlm.nih.gov/pubmed/33136526 http://dx.doi.org/10.1080/19420862.2020.1836713

Ejemplares similares

A novel format for recombinant antibody-interleukin-2 fusion proteins exhibits superior tumor-targeting properties in vivo
por: Ongaro, Tiziano, et al.
Publicado: (2020)

Generation and in vivo validation of an IL-12 fusion protein based on a novel anti-human FAP monoclonal antibody
por: Nadal, Lisa, et al.
Publicado: (2022)

Imaging the Alternatively Spliced D Domain of Tenascin C in a Preclinical Model of Inflammatory Bowel Disease
por: Zhang, Liang, et al.
Publicado: (2022)

Elevated glucose alters global gene expression and tenascin-C alternative splicing in mesangial cells
por: Vega, Maria E., et al.
Publicado: (2020)

Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C
Publicado: (1994)

Focal adhesion integrity is downregulated by the alternatively spliced domain of human tenascin [published erratum appears in J Cell Biol 1992 Feb;116(3):833]
Publicado: (1991)

Domain‐specific CD6 monoclonal antibodies identify CD6 isoforms generated by alternative‐splicing
por: Santos, Rita F., et al.
Publicado: (2019)

The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C
Publicado: (1994)

In Vivo and In Vitro Expression of Tenascin by Human Thymic Microenvironmental Cells
por: Freitas, Claudia Sondermann, et al.
Publicado: (1995)

Design and Characterization of Novel Antibody-Cytokine Fusion Proteins Based on Interleukin-21
por: Di Nitto, Cesare, et al.
Publicado: (2022)

Tenascin turns on the EGFR
por: Jegalian, Karin
Publicado: (2001)

The evolution of tenascins and fibronectin
por: Adams, Josephine C, et al.
Publicado: (2015)

Invasion of Melanoma in Double Knockout Mice Lacking Tenascin‐X and Tenascin‐C
por: Matsumoto, Ken‐ichi, et al.
Publicado: (2002)

Tenascin is associated with chondrogenic and osteogenic differentiation in vivo and promotes chondrogenesis in vitro
Publicado: (1987)

Tenascins Interfere With Remyelination in an Ex Vivo Cerebellar Explant Model of Demyelination
por: Bauch, Juliane, et al.
Publicado: (2022)

Novel Human Tenascin-C Function-Blocking Camel Single Domain Nanobodies
por: Dhaouadi, Sayda, et al.
Publicado: (2021)

Different Functions of Recombinantly Expressed Domains of Tenascin-C in Glial Scar Formation
por: Bijelić, Dunja, et al.
Publicado: (2021)

In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin
por: Laustriat, Delphine, et al.
Publicado: (2015)

In Vivo Reporters for Visualizing Alternative Splicing of Hormonal Genes
por: Kashkan, Ivan, et al.
Publicado: (2020)

Site-specific HNK-1 epitope on alternatively spliced fibronectin type-III repeats in tenascin-C promotes neurite outgrowth of hippocampal neurons through contactin-1
por: Nakamura, Ayasa, et al.
Publicado: (2019)

Characterization of functional domains of the tenascin-R (restrictin) polypeptide: cell attachment site, binding with F11, and enhancement of F11-mediated neurite outgrowth by tenascin-R
Publicado: (1995)

Association of invasion-promoting tenascin-C additional domains with breast cancers in young women
por: Guttery, David S, et al.
Publicado: (2010)

Corrigendum: Different Functions of Recombinantly Expressed Domains of Tenascin-C in Glial Scar Formation
por: Bijelić, Dunja, et al.
Publicado: (2021)

Induction of tenascin in healing wounds
Publicado: (1988)

Tenascin Supports Lymphocyte Rolling
por: Clark, Rachael A., et al.
Publicado: (1997)

Advances in tenascin-C biology
por: Midwood, Kim S., et al.
Publicado: (2011)

Tenascin-C and integrins in cancer
por: Yoshida, Toshimichi, et al.
Publicado: (2015)

Transcriptional regulation of tenascin genes
por: Chiovaro, Francesca, et al.
Publicado: (2015)

Immunosuppression via Tenascin-C
por: Bellone, Matteo, et al.
Publicado: (2015)

Tenascin-X and the pick of destiny
por: Short, Ben
Publicado: (2014)

Tenascin C in Lung Diseases
por: Donovan, Chantal, et al.
Publicado: (2023)

Differential Recruitment of Pre-mRNA Splicing Factors to Alternatively Spliced Transcripts In Vivo
por: Mabon, Stephen A, et al.
Publicado: (2005)

An Engineered IFNγ-Antibody Fusion Protein with Improved Tumor-Homing Properties
por: Di Nitto, Cesare, et al.
Publicado: (2023)

Phage-Derived Fully Human Monoclonal Antibody Fragments to Human Vascular Endothelial Growth Factor-C Block Its Interaction with VEGF Receptor-2 and 3
por: Rinderknecht, Matthias, et al.
Publicado: (2010)

Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis
Publicado: (1991)

Early Days of Tenascin-R Research: Two Approaches Discovered and Shed Light on Tenascin-R
por: Rathjen, Fritz G., et al.
Publicado: (2021)

Identification of CELF splicing activation and repression domains in vivo
por: Han, Jin, et al.
Publicado: (2005)

Predicting the Impact of Alternative Splicing on Plant MADS Domain Protein Function
por: Severing, Edouard I., et al.
Publicado: (2012)

Alternative Splicing of the RAGE Cytoplasmic Domain Regulates Cell Signaling and Function
por: Jules, Joel, et al.
Publicado: (2013)

Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumors
por: Brellier, Florence, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pratdkrbh6n42na5h9lorofucn