Pancreatic Ductal Adenocarcinoma: Characteristics of Tumor Microenvironment and Barriers to Treatment

Pancreatic ductal adenocarcinoma remains a highly aggressive disease, with a 5-year relative survival rate of 10%. Numerous barriers to treatment exist, such as dense desmoplasia, infiltration of immune suppressor cells, inhibitory cytokines, low effector T-cell infiltration, and low tumor mutationa...

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Detalles Bibliográficos
Autores principales: Kane, Sujata, Engelhart, Anne, Guadagno, Jessica, Jones, Aaron, Usoro, Innis, Brutcher, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Harborside Press LLC 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646635/
https://www.ncbi.nlm.nih.gov/pubmed/33575066
http://dx.doi.org/10.6004/jadpro.2020.11.7.4
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author Kane, Sujata
Engelhart, Anne
Guadagno, Jessica
Jones, Aaron
Usoro, Innis
Brutcher, Edith
author_facet Kane, Sujata
Engelhart, Anne
Guadagno, Jessica
Jones, Aaron
Usoro, Innis
Brutcher, Edith
author_sort Kane, Sujata
collection PubMed
description Pancreatic ductal adenocarcinoma remains a highly aggressive disease, with a 5-year relative survival rate of 10%. Numerous barriers to treatment exist, such as dense desmoplasia, infiltration of immune suppressor cells, inhibitory cytokines, low effector T-cell infiltration, and low tumor mutational burden. These factors help form a highly suppressive tumor microenvironment unique to pancreatic ductal adenocarcinoma. This review outlines barriers to treatment of pancreatic ductal adenocarcinoma by discussing the unique characteristics of the pancreatic tumor microenvironment and the factors that contribute to making pancreatic ductal adenocarcinoma such a challenging disease to treat.
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spelling pubmed-76466352021-02-10 Pancreatic Ductal Adenocarcinoma: Characteristics of Tumor Microenvironment and Barriers to Treatment Kane, Sujata Engelhart, Anne Guadagno, Jessica Jones, Aaron Usoro, Innis Brutcher, Edith J Adv Pract Oncol Review Pancreatic ductal adenocarcinoma remains a highly aggressive disease, with a 5-year relative survival rate of 10%. Numerous barriers to treatment exist, such as dense desmoplasia, infiltration of immune suppressor cells, inhibitory cytokines, low effector T-cell infiltration, and low tumor mutational burden. These factors help form a highly suppressive tumor microenvironment unique to pancreatic ductal adenocarcinoma. This review outlines barriers to treatment of pancreatic ductal adenocarcinoma by discussing the unique characteristics of the pancreatic tumor microenvironment and the factors that contribute to making pancreatic ductal adenocarcinoma such a challenging disease to treat. Harborside Press LLC 2020 2020-09-01 /pmc/articles/PMC7646635/ /pubmed/33575066 http://dx.doi.org/10.6004/jadpro.2020.11.7.4 Text en © 2020 Harborside™ http://creativecommons.org/licenses/by-nc-nd/3.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial Non-Derivative License, which permits unrestricted non-commercial and non-derivative use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Kane, Sujata
Engelhart, Anne
Guadagno, Jessica
Jones, Aaron
Usoro, Innis
Brutcher, Edith
Pancreatic Ductal Adenocarcinoma: Characteristics of Tumor Microenvironment and Barriers to Treatment
title Pancreatic Ductal Adenocarcinoma: Characteristics of Tumor Microenvironment and Barriers to Treatment
title_full Pancreatic Ductal Adenocarcinoma: Characteristics of Tumor Microenvironment and Barriers to Treatment
title_fullStr Pancreatic Ductal Adenocarcinoma: Characteristics of Tumor Microenvironment and Barriers to Treatment
title_full_unstemmed Pancreatic Ductal Adenocarcinoma: Characteristics of Tumor Microenvironment and Barriers to Treatment
title_short Pancreatic Ductal Adenocarcinoma: Characteristics of Tumor Microenvironment and Barriers to Treatment
title_sort pancreatic ductal adenocarcinoma: characteristics of tumor microenvironment and barriers to treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646635/
https://www.ncbi.nlm.nih.gov/pubmed/33575066
http://dx.doi.org/10.6004/jadpro.2020.11.7.4
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