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Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations
The human infection caused by the novel SARS-CoV-2 is a public health emergency of international concern. Although the disease associated to this virus, named COVID-19, mainly affects the lungs, the infection can spread to extrapulmonary tissues, causing multiorgan involvement in severely ill patien...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646711/ https://www.ncbi.nlm.nih.gov/pubmed/33159236 http://dx.doi.org/10.1007/s00403-020-02156-0 |
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author | Garduño-Soto, Myriam Choreño-Parra, Jose Alberto Cazarin-Barrientos, Jorge |
author_facet | Garduño-Soto, Myriam Choreño-Parra, Jose Alberto Cazarin-Barrientos, Jorge |
author_sort | Garduño-Soto, Myriam |
collection | PubMed |
description | The human infection caused by the novel SARS-CoV-2 is a public health emergency of international concern. Although the disease associated to this virus, named COVID-19, mainly affects the lungs, the infection can spread to extrapulmonary tissues, causing multiorgan involvement in severely ill patients. The broad infective capacity of SARS-CoV-2 is related to the pattern of expression of the viral entry factors ACE2 and TMPRSS2 in human tissues. As such, the respiratory and gastrointestinal tracts are at high risk for SARS-CoV-2 infection due to their high expression of ACE2 and TMPRSS2, which explains the clinical phenotype described in the vast majority of infected patients that includes pneumonia and diarrhea. Recently, preoccupation about the potential of the virus to infect the skin has been raised by dermatologists due to the increasing observations of cutaneous manifestations in patients with SARS-CoV-2 infection. Although there is little evidence of the expression of ACE2 and TMPRSS2 in the normal skin, the dermatological findings observed among COVID-19 patients warrants further investigation to delineate the mechanisms of skin affection after SARS-CoV-2 infection. Here, we provide a summary of the dermatological findings observed among patients with laboratory-confirmed SARS-CoV-2 infection based on recent reports. In addition, we analyze possible mechanisms of skin injury in COVID-19 patients and discuss about the risk of individuals with chronic skin conditions for SARS-CoV-2 infection. The present review constitutes a useful informative tool to improve our understanding of the pathophysiological mechanisms of COVID-19 and the possible implications of the current pandemic in dermatology. |
format | Online Article Text |
id | pubmed-7646711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-76467112020-11-06 Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations Garduño-Soto, Myriam Choreño-Parra, Jose Alberto Cazarin-Barrientos, Jorge Arch Dermatol Res Review The human infection caused by the novel SARS-CoV-2 is a public health emergency of international concern. Although the disease associated to this virus, named COVID-19, mainly affects the lungs, the infection can spread to extrapulmonary tissues, causing multiorgan involvement in severely ill patients. The broad infective capacity of SARS-CoV-2 is related to the pattern of expression of the viral entry factors ACE2 and TMPRSS2 in human tissues. As such, the respiratory and gastrointestinal tracts are at high risk for SARS-CoV-2 infection due to their high expression of ACE2 and TMPRSS2, which explains the clinical phenotype described in the vast majority of infected patients that includes pneumonia and diarrhea. Recently, preoccupation about the potential of the virus to infect the skin has been raised by dermatologists due to the increasing observations of cutaneous manifestations in patients with SARS-CoV-2 infection. Although there is little evidence of the expression of ACE2 and TMPRSS2 in the normal skin, the dermatological findings observed among COVID-19 patients warrants further investigation to delineate the mechanisms of skin affection after SARS-CoV-2 infection. Here, we provide a summary of the dermatological findings observed among patients with laboratory-confirmed SARS-CoV-2 infection based on recent reports. In addition, we analyze possible mechanisms of skin injury in COVID-19 patients and discuss about the risk of individuals with chronic skin conditions for SARS-CoV-2 infection. The present review constitutes a useful informative tool to improve our understanding of the pathophysiological mechanisms of COVID-19 and the possible implications of the current pandemic in dermatology. Springer Berlin Heidelberg 2020-11-06 2021 /pmc/articles/PMC7646711/ /pubmed/33159236 http://dx.doi.org/10.1007/s00403-020-02156-0 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Garduño-Soto, Myriam Choreño-Parra, Jose Alberto Cazarin-Barrientos, Jorge Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations |
title | Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations |
title_full | Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations |
title_fullStr | Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations |
title_full_unstemmed | Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations |
title_short | Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations |
title_sort | dermatological aspects of sars-cov-2 infection: mechanisms and manifestations |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646711/ https://www.ncbi.nlm.nih.gov/pubmed/33159236 http://dx.doi.org/10.1007/s00403-020-02156-0 |
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