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Metformin protects high glucose-cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway

Tissue damage in diabetes is at least partly due to elevated reactive oxygen species production by the mitochondrial respiratory chain during hyperglycemia. Sustained hyperglycemia results in mitochondrial dysfunction and the abnormal expression of mitochondrial genes, such as NADH: Ubiquinone oxido...

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Detalles Bibliográficos
Autores principales:	Liu, Xiang-Dong, Li, Yong-Guang, Wang, Guang-Yu, Bi, Ya-Guang, Zhao, Yu, Yan, Mei-Ling, Liu, Xuebo, Wei, Meng, Wan, Li-Li, Zhang, Qing-Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646981/ https://www.ncbi.nlm.nih.gov/pubmed/33174032 http://dx.doi.org/10.3892/mmr.2020.11599

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