Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children

OBJECTIVE: Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. METHOD: Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of Q...

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Detalles Bibliográficos
Autores principales: Sanogo, Bintou, Ouermi, Alain Saga, Barro, Makoura, Millogo, Anselme, Ouattara, Ad Bafa Ibrahim, Abdoul Salam, Ouédraogo, Nacro, Boubacar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647084/
https://www.ncbi.nlm.nih.gov/pubmed/33156871
http://dx.doi.org/10.1371/journal.pone.0241789
Descripción
Sumario:OBJECTIVE: Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. METHOD: Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB. RESULTS: Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%. CONCLUSION: QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.

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