Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children

OBJECTIVE: Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. METHOD: Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of Q...

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Autores principales: Sanogo, Bintou, Ouermi, Alain Saga, Barro, Makoura, Millogo, Anselme, Ouattara, Ad Bafa Ibrahim, Abdoul Salam, Ouédraogo, Nacro, Boubacar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647084/
https://www.ncbi.nlm.nih.gov/pubmed/33156871
http://dx.doi.org/10.1371/journal.pone.0241789
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author Sanogo, Bintou
Ouermi, Alain Saga
Barro, Makoura
Millogo, Anselme
Ouattara, Ad Bafa Ibrahim
Abdoul Salam, Ouédraogo
Nacro, Boubacar
author_facet Sanogo, Bintou
Ouermi, Alain Saga
Barro, Makoura
Millogo, Anselme
Ouattara, Ad Bafa Ibrahim
Abdoul Salam, Ouédraogo
Nacro, Boubacar
author_sort Sanogo, Bintou
collection PubMed
description OBJECTIVE: Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. METHOD: Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB. RESULTS: Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%. CONCLUSION: QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.
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spelling pubmed-76470842020-11-16 Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children Sanogo, Bintou Ouermi, Alain Saga Barro, Makoura Millogo, Anselme Ouattara, Ad Bafa Ibrahim Abdoul Salam, Ouédraogo Nacro, Boubacar PLoS One Research Article OBJECTIVE: Evaluate the performance of QuantiFERON ® -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children. METHOD: Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58/63 HIV-infected children who were suspected of having TB. RESULTS: Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV/NPV respectively 85.71% and 54.90%. CONCLUSION: QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country. Public Library of Science 2020-11-06 /pmc/articles/PMC7647084/ /pubmed/33156871 http://dx.doi.org/10.1371/journal.pone.0241789 Text en © 2020 Sanogo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sanogo, Bintou
Ouermi, Alain Saga
Barro, Makoura
Millogo, Anselme
Ouattara, Ad Bafa Ibrahim
Abdoul Salam, Ouédraogo
Nacro, Boubacar
Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children
title Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children
title_full Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children
title_fullStr Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children
title_full_unstemmed Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children
title_short Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the diagnosis of active tuberculosis in HIV-infected children
title_sort performance of a lymphocyte t interferon gamma test (quantiferon-tb gold in tube) in the diagnosis of active tuberculosis in hiv-infected children
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647084/
https://www.ncbi.nlm.nih.gov/pubmed/33156871
http://dx.doi.org/10.1371/journal.pone.0241789
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