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Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database

During sepsis, platelets dysfunction contributes to organ dysfunction. Studies on platelets dysfunction in the long-term prognosis of sepsis are lacking. The aim of this study was to assess the role of platelets in the long-term prognosis of sepsis patients. A total of 4576 sepsis patients were extr...

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Autores principales: Zhao, Lina, Zhao, Lijiao, Wang, Yun ying, Yang, Fei, Chen, Zhuang, Yu, Qing, Shi, Hui, Huang, Shiying, Zhao, Xiaoli, Xiu, Limei, Li, Xiaolu, Li, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647525/
https://www.ncbi.nlm.nih.gov/pubmed/33157998
http://dx.doi.org/10.1097/MD.0000000000023151
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author Zhao, Lina
Zhao, Lijiao
Wang, Yun ying
Yang, Fei
Chen, Zhuang
Yu, Qing
Shi, Hui
Huang, Shiying
Zhao, Xiaoli
Xiu, Limei
Li, Xiaolu
Li, Yun
author_facet Zhao, Lina
Zhao, Lijiao
Wang, Yun ying
Yang, Fei
Chen, Zhuang
Yu, Qing
Shi, Hui
Huang, Shiying
Zhao, Xiaoli
Xiu, Limei
Li, Xiaolu
Li, Yun
author_sort Zhao, Lina
collection PubMed
description During sepsis, platelets dysfunction contributes to organ dysfunction. Studies on platelets dysfunction in the long-term prognosis of sepsis are lacking. The aim of this study was to assess the role of platelets in the long-term prognosis of sepsis patients. A total of 4576 sepsis patients were extracted from MIMIC III Database. Survival was analyzed by the Kaplan-Meier method. Univariate and multivariate cox analyses were performed to identify prognostic factors. Significant prognostic factors were combined to build a nomogram to predict 1 year overall survival (OS). The discriminative ability and predictive accuracy of the nomogram were evaluated using the receiver operating characteristic curve (ROC) analysis and calibration curves used for sepsis. The more abnormal the platelet level, the worse prognosis of patients. After final regression analysis, age, blood urea nitrogen, platelets, international normalized ratio, partial thromboplastin time, potassium, hemoglobin, white blood cell count, organ failures were found to be independent predictors of 1 year OS of sepsis patient and were entered into a nomogram. The nomogram showed a robust discrimination, with an area under the receiver operating characteristic curve of 0.752. The calibration curves for the probability of the prognosis of sepsis patients showed optimal agreement between the probability as predicted by the nomogram and the actual probability. Platelet was an independent prognostic predictor of 1 year OS for patients with sepsis. Platelet-related nomogram that can predict the 1 year OS of sepsis patients. It revealed optimal discrimination and calibration, indicating that the nomogram may have clinical utility.
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spelling pubmed-76475252020-11-09 Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database Zhao, Lina Zhao, Lijiao Wang, Yun ying Yang, Fei Chen, Zhuang Yu, Qing Shi, Hui Huang, Shiying Zhao, Xiaoli Xiu, Limei Li, Xiaolu Li, Yun Medicine (Baltimore) 3900 During sepsis, platelets dysfunction contributes to organ dysfunction. Studies on platelets dysfunction in the long-term prognosis of sepsis are lacking. The aim of this study was to assess the role of platelets in the long-term prognosis of sepsis patients. A total of 4576 sepsis patients were extracted from MIMIC III Database. Survival was analyzed by the Kaplan-Meier method. Univariate and multivariate cox analyses were performed to identify prognostic factors. Significant prognostic factors were combined to build a nomogram to predict 1 year overall survival (OS). The discriminative ability and predictive accuracy of the nomogram were evaluated using the receiver operating characteristic curve (ROC) analysis and calibration curves used for sepsis. The more abnormal the platelet level, the worse prognosis of patients. After final regression analysis, age, blood urea nitrogen, platelets, international normalized ratio, partial thromboplastin time, potassium, hemoglobin, white blood cell count, organ failures were found to be independent predictors of 1 year OS of sepsis patient and were entered into a nomogram. The nomogram showed a robust discrimination, with an area under the receiver operating characteristic curve of 0.752. The calibration curves for the probability of the prognosis of sepsis patients showed optimal agreement between the probability as predicted by the nomogram and the actual probability. Platelet was an independent prognostic predictor of 1 year OS for patients with sepsis. Platelet-related nomogram that can predict the 1 year OS of sepsis patients. It revealed optimal discrimination and calibration, indicating that the nomogram may have clinical utility. Lippincott Williams & Wilkins 2020-11-06 /pmc/articles/PMC7647525/ /pubmed/33157998 http://dx.doi.org/10.1097/MD.0000000000023151 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0
spellingShingle 3900
Zhao, Lina
Zhao, Lijiao
Wang, Yun ying
Yang, Fei
Chen, Zhuang
Yu, Qing
Shi, Hui
Huang, Shiying
Zhao, Xiaoli
Xiu, Limei
Li, Xiaolu
Li, Yun
Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database
title Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database
title_full Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database
title_fullStr Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database
title_full_unstemmed Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database
title_short Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database
title_sort platelets as a prognostic marker for sepsis: a cohort study from the mimic-iii database
topic 3900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647525/
https://www.ncbi.nlm.nih.gov/pubmed/33157998
http://dx.doi.org/10.1097/MD.0000000000023151
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