Cargando…
Asthma susceptible genes in children: A meta-analysis
BACKGROUND: During the last decade, a number of studies have evaluated the potential association between some genetic polymorphisms and childhood asthma risk, however, the results of published studies appear conflicts. The aim of the present study was to investigate association between genetic polym...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647564/ https://www.ncbi.nlm.nih.gov/pubmed/33157959 http://dx.doi.org/10.1097/MD.0000000000023051 |
_version_ | 1783606936140251136 |
---|---|
author | Ruan, Zhen Shi, Zhaoling Zhang, Guocheng Kou, Jiushe Ding, Hui |
author_facet | Ruan, Zhen Shi, Zhaoling Zhang, Guocheng Kou, Jiushe Ding, Hui |
author_sort | Ruan, Zhen |
collection | PubMed |
description | BACKGROUND: During the last decade, a number of studies have evaluated the potential association between some genetic polymorphisms and childhood asthma risk, however, the results of published studies appear conflicts. The aim of the present study was to investigate association between genetic polymorphisms and pediatric asthma. METHODS: Relevant studies were searched in PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang, and Weipu database. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to evaluate the strength of the associations. RESULTS: Fifty five case-control studies were finally included in this meta-analysis, including 17,971 pediatric asthma cases and 17,500 controls. Eighteen polymorphisms were identified, of which, 9 polymorphisms were found to be associated with asthma risk in overall populations: IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4,ORMDL3 rs7216389, VDR FokI, VDR TaqI. Furthermore, IL-13 +2044G/A, IL-4 -590C/T, ADAM33 T2, ADAM33 T1, VDR BsmI polymorphisms may cause an increased risk of asthma among Chinese children. CONCLUSIONS: This meta-analysis found that IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4,ORMDL3 rs7216389, VDR FokI, and VDR TaqI polymorphisms might be risk factors for childhood asthma. Further study with large population and more ethnicities is needed to estimate these associations. |
format | Online Article Text |
id | pubmed-7647564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-76475642020-11-09 Asthma susceptible genes in children: A meta-analysis Ruan, Zhen Shi, Zhaoling Zhang, Guocheng Kou, Jiushe Ding, Hui Medicine (Baltimore) 6200 BACKGROUND: During the last decade, a number of studies have evaluated the potential association between some genetic polymorphisms and childhood asthma risk, however, the results of published studies appear conflicts. The aim of the present study was to investigate association between genetic polymorphisms and pediatric asthma. METHODS: Relevant studies were searched in PubMed, Embase, Web of Science, CNKI (China National Knowledge Infrastructure), Wanfang, and Weipu database. Pooled odds ratios (OR) with 95% confidence interval (CI) were calculated to evaluate the strength of the associations. RESULTS: Fifty five case-control studies were finally included in this meta-analysis, including 17,971 pediatric asthma cases and 17,500 controls. Eighteen polymorphisms were identified, of which, 9 polymorphisms were found to be associated with asthma risk in overall populations: IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4,ORMDL3 rs7216389, VDR FokI, VDR TaqI. Furthermore, IL-13 +2044G/A, IL-4 -590C/T, ADAM33 T2, ADAM33 T1, VDR BsmI polymorphisms may cause an increased risk of asthma among Chinese children. CONCLUSIONS: This meta-analysis found that IL-13 +2044G/A, IL-4 -590C/T, ADAM33 F+1, ADAM33 T2, ADAM33 T1, ADAM33 ST+4,ORMDL3 rs7216389, VDR FokI, and VDR TaqI polymorphisms might be risk factors for childhood asthma. Further study with large population and more ethnicities is needed to estimate these associations. Lippincott Williams & Wilkins 2020-11-06 /pmc/articles/PMC7647564/ /pubmed/33157959 http://dx.doi.org/10.1097/MD.0000000000023051 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0 |
spellingShingle | 6200 Ruan, Zhen Shi, Zhaoling Zhang, Guocheng Kou, Jiushe Ding, Hui Asthma susceptible genes in children: A meta-analysis |
title | Asthma susceptible genes in children: A meta-analysis |
title_full | Asthma susceptible genes in children: A meta-analysis |
title_fullStr | Asthma susceptible genes in children: A meta-analysis |
title_full_unstemmed | Asthma susceptible genes in children: A meta-analysis |
title_short | Asthma susceptible genes in children: A meta-analysis |
title_sort | asthma susceptible genes in children: a meta-analysis |
topic | 6200 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647564/ https://www.ncbi.nlm.nih.gov/pubmed/33157959 http://dx.doi.org/10.1097/MD.0000000000023051 |
work_keys_str_mv | AT ruanzhen asthmasusceptiblegenesinchildrenametaanalysis AT shizhaoling asthmasusceptiblegenesinchildrenametaanalysis AT zhangguocheng asthmasusceptiblegenesinchildrenametaanalysis AT koujiushe asthmasusceptiblegenesinchildrenametaanalysis AT dinghui asthmasusceptiblegenesinchildrenametaanalysis |