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Efficacy and safety of platelet-rich plasma in the treatment of severe burns: A protocol for systematic review and meta analysis
BACKGROUND: In recent years, platelet-rich plasma (PRP) has been used in burn wound repair, plastic surgery, bone and tendon ligament injury repair and other treatment at home and abroad. Clinical studies indicate that PRP has a good curative effect on repairing burn wounds. The residual wounds form...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647582/ https://www.ncbi.nlm.nih.gov/pubmed/33157943 http://dx.doi.org/10.1097/MD.0000000000023001 |
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author | Chen, Zhao Wu, Yuyan Turxun, Nurlan Shen, Yingjie Zhang, Xue |
author_facet | Chen, Zhao Wu, Yuyan Turxun, Nurlan Shen, Yingjie Zhang, Xue |
author_sort | Chen, Zhao |
collection | PubMed |
description | BACKGROUND: In recent years, platelet-rich plasma (PRP) has been used in burn wound repair, plastic surgery, bone and tendon ligament injury repair and other treatment at home and abroad. Clinical studies indicate that PRP has a good curative effect on repairing burn wounds. The residual wounds formed after large area severe burns are difficult to cure and have recurrent attacks. Because the action mechanism of PRP is unclear, its clinical efficacy of PRP in repairing severe burn wounds is controversial. And there is no relevant systematic evaluation of PRP in repairing severe burn wounds now. OBJECTIVE: Meta analysis was used to evaluate the efficacy and safety of PRP in repairing severe burn wounds. METHODS: Randomized controlled clinical trial of using PRP to repair severe burn wounds were retrieved by computer WanFang, China National Knowledge Infrastructure, China Science and Technology Journal Database, China Biology Medicine disc, Embase, PubMed, Web of Science and Cochrane Library from the establishment of the database to September 2020. Two researchers independently extract data and assess the quality of the included literature, and Meta analysis of the included literature is carried out by using RevMan5.3 software. RESULTS: In this study, the efficacy and safety of PRP in repairing severe burn wounds are evaluated from the aspects of wound healing rate, wound healing time, scar index, visual simulation score, the number of layers of dressing, the number of times of changing gauze, frequency of dressing change, the positive rate of wound bacterial culture and the incidence of inflammatory reaction. CONCLUSIONS: PRP has a good curative effect on the repair of severe burn wounds. This study provides reliable evidence for the clinical use of PRP in the clinical repair of severe burn wounds. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/FG682 |
format | Online Article Text |
id | pubmed-7647582 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-76475822020-11-09 Efficacy and safety of platelet-rich plasma in the treatment of severe burns: A protocol for systematic review and meta analysis Chen, Zhao Wu, Yuyan Turxun, Nurlan Shen, Yingjie Zhang, Xue Medicine (Baltimore) 4000 BACKGROUND: In recent years, platelet-rich plasma (PRP) has been used in burn wound repair, plastic surgery, bone and tendon ligament injury repair and other treatment at home and abroad. Clinical studies indicate that PRP has a good curative effect on repairing burn wounds. The residual wounds formed after large area severe burns are difficult to cure and have recurrent attacks. Because the action mechanism of PRP is unclear, its clinical efficacy of PRP in repairing severe burn wounds is controversial. And there is no relevant systematic evaluation of PRP in repairing severe burn wounds now. OBJECTIVE: Meta analysis was used to evaluate the efficacy and safety of PRP in repairing severe burn wounds. METHODS: Randomized controlled clinical trial of using PRP to repair severe burn wounds were retrieved by computer WanFang, China National Knowledge Infrastructure, China Science and Technology Journal Database, China Biology Medicine disc, Embase, PubMed, Web of Science and Cochrane Library from the establishment of the database to September 2020. Two researchers independently extract data and assess the quality of the included literature, and Meta analysis of the included literature is carried out by using RevMan5.3 software. RESULTS: In this study, the efficacy and safety of PRP in repairing severe burn wounds are evaluated from the aspects of wound healing rate, wound healing time, scar index, visual simulation score, the number of layers of dressing, the number of times of changing gauze, frequency of dressing change, the positive rate of wound bacterial culture and the incidence of inflammatory reaction. CONCLUSIONS: PRP has a good curative effect on the repair of severe burn wounds. This study provides reliable evidence for the clinical use of PRP in the clinical repair of severe burn wounds. OSF REGISTRATION NUMBER: DOI 10.17605/OSF.IO/FG682 Lippincott Williams & Wilkins 2020-11-06 /pmc/articles/PMC7647582/ /pubmed/33157943 http://dx.doi.org/10.1097/MD.0000000000023001 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 4000 Chen, Zhao Wu, Yuyan Turxun, Nurlan Shen, Yingjie Zhang, Xue Efficacy and safety of platelet-rich plasma in the treatment of severe burns: A protocol for systematic review and meta analysis |
title | Efficacy and safety of platelet-rich plasma in the treatment of severe burns: A protocol for systematic review and meta analysis |
title_full | Efficacy and safety of platelet-rich plasma in the treatment of severe burns: A protocol for systematic review and meta analysis |
title_fullStr | Efficacy and safety of platelet-rich plasma in the treatment of severe burns: A protocol for systematic review and meta analysis |
title_full_unstemmed | Efficacy and safety of platelet-rich plasma in the treatment of severe burns: A protocol for systematic review and meta analysis |
title_short | Efficacy and safety of platelet-rich plasma in the treatment of severe burns: A protocol for systematic review and meta analysis |
title_sort | efficacy and safety of platelet-rich plasma in the treatment of severe burns: a protocol for systematic review and meta analysis |
topic | 4000 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647582/ https://www.ncbi.nlm.nih.gov/pubmed/33157943 http://dx.doi.org/10.1097/MD.0000000000023001 |
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