A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia

The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of (18)FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imagi...

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Detalles Bibliográficos
Autores principales: Yassin, Mohamed A., Nehmeh, Sadek A., Nashwan, Abdulqadir J., Kohla, Samah A., Mohamed, Shehab F., Ismail, Omar M., Sabbagh, Ahmad Al, Ibrahim, Firyal, Soliman, Dina S., Szabados, Lajos, Fayad, Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
4800
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647608/
https://www.ncbi.nlm.nih.gov/pubmed/33157979
http://dx.doi.org/10.1097/MD.0000000000023088
Descripción
Sumario:The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of (18)FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden. This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017

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