A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia

The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of (18)FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imagi...

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Autores principales: Yassin, Mohamed A., Nehmeh, Sadek A., Nashwan, Abdulqadir J., Kohla, Samah A., Mohamed, Shehab F., Ismail, Omar M., Sabbagh, Ahmad Al, Ibrahim, Firyal, Soliman, Dina S., Szabados, Lajos, Fayad, Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
4800
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647608/
https://www.ncbi.nlm.nih.gov/pubmed/33157979
http://dx.doi.org/10.1097/MD.0000000000023088
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author Yassin, Mohamed A.
Nehmeh, Sadek A.
Nashwan, Abdulqadir J.
Kohla, Samah A.
Mohamed, Shehab F.
Ismail, Omar M.
Sabbagh, Ahmad Al
Ibrahim, Firyal
Soliman, Dina S.
Szabados, Lajos
Fayad, Hadi
author_facet Yassin, Mohamed A.
Nehmeh, Sadek A.
Nashwan, Abdulqadir J.
Kohla, Samah A.
Mohamed, Shehab F.
Ismail, Omar M.
Sabbagh, Ahmad Al
Ibrahim, Firyal
Soliman, Dina S.
Szabados, Lajos
Fayad, Hadi
author_sort Yassin, Mohamed A.
collection PubMed
description The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of (18)FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden. This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017
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spelling pubmed-76476082020-11-09 A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia Yassin, Mohamed A. Nehmeh, Sadek A. Nashwan, Abdulqadir J. Kohla, Samah A. Mohamed, Shehab F. Ismail, Omar M. Sabbagh, Ahmad Al Ibrahim, Firyal Soliman, Dina S. Szabados, Lajos Fayad, Hadi Medicine (Baltimore) 4800 The objectives of this research project are to study in patients with primary myelofibrosis (PMF) and Essential Thrombocythemia (ET); (1) the uptake patterns of (18)FLT-PET (FLT-PET) and its value in diagnosing, staging, and treatment response monitoring of malignant hematopoiesis, (2) compare imaging findings from FLT-PET with bone marrow biopsy (standard of care), and (3) associate FLT-PET uptake patterns with genetic makeup such as JAK2 (Janus kinase 2), CALR (Calreticulin), MPL (myeloproliferative leukemia protein), Triple negative disease, and allele burden. This trial is registered in ClinicalTrials.gov with number NCT03116542. Protocol version: Mar 2017 Lippincott Williams & Wilkins 2020-11-06 /pmc/articles/PMC7647608/ /pubmed/33157979 http://dx.doi.org/10.1097/MD.0000000000023088 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 4800
Yassin, Mohamed A.
Nehmeh, Sadek A.
Nashwan, Abdulqadir J.
Kohla, Samah A.
Mohamed, Shehab F.
Ismail, Omar M.
Sabbagh, Ahmad Al
Ibrahim, Firyal
Soliman, Dina S.
Szabados, Lajos
Fayad, Hadi
A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
title A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
title_full A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
title_fullStr A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
title_full_unstemmed A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
title_short A study of (18)F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
title_sort study of (18)f-flt positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia
topic 4800
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647608/
https://www.ncbi.nlm.nih.gov/pubmed/33157979
http://dx.doi.org/10.1097/MD.0000000000023088
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