Liquid Biopsy in Breast Cancer

In recent years, the blood-based analysis of circulating tumour cells (CTCs) and nucleic acids (DNA/RNA), otherwise known as liquid biopsy, has become increasingly important in breast cancer. Numerous trials have already underscored the high prognostic significance of CTC detection in both early and...

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Autores principales: Banys-Paluchowski, Maggie, Krawczyk, Natalia, Fehm, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647718/
https://www.ncbi.nlm.nih.gov/pubmed/33173237
http://dx.doi.org/10.1055/a-1124-7225
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author Banys-Paluchowski, Maggie
Krawczyk, Natalia
Fehm, Tanja
author_facet Banys-Paluchowski, Maggie
Krawczyk, Natalia
Fehm, Tanja
author_sort Banys-Paluchowski, Maggie
collection PubMed
description In recent years, the blood-based analysis of circulating tumour cells (CTCs) and nucleic acids (DNA/RNA), otherwise known as liquid biopsy, has become increasingly important in breast cancer. Numerous trials have already underscored the high prognostic significance of CTC detection in both early and metastatic stages. Moreover, the changes in CTC levels and circulating tumour DNA (ctDNA) during the course of the disease correlate with the response to treatment. Research currently focuses on liquid-biopsy based therapeutic interventions in metastatic breast cancer. In this context, alpelisib, a PI3K inhibitor, was the first agent to be approved by FDA and EMA.
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spelling pubmed-76477182020-11-09 Liquid Biopsy in Breast Cancer Banys-Paluchowski, Maggie Krawczyk, Natalia Fehm, Tanja Geburtshilfe Frauenheilkd In recent years, the blood-based analysis of circulating tumour cells (CTCs) and nucleic acids (DNA/RNA), otherwise known as liquid biopsy, has become increasingly important in breast cancer. Numerous trials have already underscored the high prognostic significance of CTC detection in both early and metastatic stages. Moreover, the changes in CTC levels and circulating tumour DNA (ctDNA) during the course of the disease correlate with the response to treatment. Research currently focuses on liquid-biopsy based therapeutic interventions in metastatic breast cancer. In this context, alpelisib, a PI3K inhibitor, was the first agent to be approved by FDA and EMA. Georg Thieme Verlag KG 2020-11 2020-11-06 /pmc/articles/PMC7647718/ /pubmed/33173237 http://dx.doi.org/10.1055/a-1124-7225 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/) https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Banys-Paluchowski, Maggie
Krawczyk, Natalia
Fehm, Tanja
Liquid Biopsy in Breast Cancer
title Liquid Biopsy in Breast Cancer
title_full Liquid Biopsy in Breast Cancer
title_fullStr Liquid Biopsy in Breast Cancer
title_full_unstemmed Liquid Biopsy in Breast Cancer
title_short Liquid Biopsy in Breast Cancer
title_sort liquid biopsy in breast cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647718/
https://www.ncbi.nlm.nih.gov/pubmed/33173237
http://dx.doi.org/10.1055/a-1124-7225
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