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The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer

Scorpion Buthus martensii Karsch -analgesic-antitumor peptide (BmK AGAP) has been used to treat diseases like tetanus, tuberculosis, apoplexy, epilepsy, spasm, migraine headaches, rheumatic pain, and cancer in China. AGAP is a distinctive long-chain scorpion toxin with a molecular mass of 7142 Da an...

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Autores principales: Richard, Seidu A., Kampo, Sylvanus, Sackey, Marian, Hechavarria, Maite Esquijarosa, Buunaaim, Alexis D. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647755/
https://www.ncbi.nlm.nih.gov/pubmed/33178316
http://dx.doi.org/10.1155/2020/4234273
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author Richard, Seidu A.
Kampo, Sylvanus
Sackey, Marian
Hechavarria, Maite Esquijarosa
Buunaaim, Alexis D. B.
author_facet Richard, Seidu A.
Kampo, Sylvanus
Sackey, Marian
Hechavarria, Maite Esquijarosa
Buunaaim, Alexis D. B.
author_sort Richard, Seidu A.
collection PubMed
description Scorpion Buthus martensii Karsch -analgesic-antitumor peptide (BmK AGAP) has been used to treat diseases like tetanus, tuberculosis, apoplexy, epilepsy, spasm, migraine headaches, rheumatic pain, and cancer in China. AGAP is a distinctive long-chain scorpion toxin with a molecular mass of 7142 Da and composed of 66 amino acids cross-linked by four disulfide bridges. Voltage-gated sodium channels (VGSCs) are present in excitable membranes and partakes in essential roles in action potentials generation as compared to the significant function of voltage-gated calcium channels (VGCCs). A total of nine genes (Na(v)1.1–Na(v)1.9) have been recognized to encode practical sodium channel isoforms. Na(v)1.3, Na(v)1.7, Na(v)1.8, and Na(v)1.9 have been recognized as potential targets for analgesics. Na(v)1.8 and Na(v)1.9 are associated with nociception initiated by inflammation signals in the neuronal pain pathway, while Na(v)1.8 is fundamental for neuropathic pain at low temperatures. AGAP has a sturdy inhibitory influence on both viscera and soma pain. AGAP potentiates the effects of MAPK inhibitors on neuropathic as well as inflammation-associated pain. AGAP downregulates the secretion of phosphorylated p38, phosphorylated JNK, and phosphorylated ERK 1/2 in vitro. AGAP has an analgesic activity which may be an effective therapeutic agent for pain management because of its downregulation of PTX3 via NF-κB and Wnt/beta-catenin signaling pathway. In cancers like colon cancer, breast cancer, lymphoma, and glioma, rAGAP was capable of blocking the proliferation. Thus, AGAP is a promising therapy for these tumors. Nevertheless, research is needed with other tumors.
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spelling pubmed-76477552020-11-10 The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer Richard, Seidu A. Kampo, Sylvanus Sackey, Marian Hechavarria, Maite Esquijarosa Buunaaim, Alexis D. B. Evid Based Complement Alternat Med Review Article Scorpion Buthus martensii Karsch -analgesic-antitumor peptide (BmK AGAP) has been used to treat diseases like tetanus, tuberculosis, apoplexy, epilepsy, spasm, migraine headaches, rheumatic pain, and cancer in China. AGAP is a distinctive long-chain scorpion toxin with a molecular mass of 7142 Da and composed of 66 amino acids cross-linked by four disulfide bridges. Voltage-gated sodium channels (VGSCs) are present in excitable membranes and partakes in essential roles in action potentials generation as compared to the significant function of voltage-gated calcium channels (VGCCs). A total of nine genes (Na(v)1.1–Na(v)1.9) have been recognized to encode practical sodium channel isoforms. Na(v)1.3, Na(v)1.7, Na(v)1.8, and Na(v)1.9 have been recognized as potential targets for analgesics. Na(v)1.8 and Na(v)1.9 are associated with nociception initiated by inflammation signals in the neuronal pain pathway, while Na(v)1.8 is fundamental for neuropathic pain at low temperatures. AGAP has a sturdy inhibitory influence on both viscera and soma pain. AGAP potentiates the effects of MAPK inhibitors on neuropathic as well as inflammation-associated pain. AGAP downregulates the secretion of phosphorylated p38, phosphorylated JNK, and phosphorylated ERK 1/2 in vitro. AGAP has an analgesic activity which may be an effective therapeutic agent for pain management because of its downregulation of PTX3 via NF-κB and Wnt/beta-catenin signaling pathway. In cancers like colon cancer, breast cancer, lymphoma, and glioma, rAGAP was capable of blocking the proliferation. Thus, AGAP is a promising therapy for these tumors. Nevertheless, research is needed with other tumors. Hindawi 2020-10-29 /pmc/articles/PMC7647755/ /pubmed/33178316 http://dx.doi.org/10.1155/2020/4234273 Text en Copyright © 2020 Seidu A. Richard et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Richard, Seidu A.
Kampo, Sylvanus
Sackey, Marian
Hechavarria, Maite Esquijarosa
Buunaaim, Alexis D. B.
The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer
title The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer
title_full The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer
title_fullStr The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer
title_full_unstemmed The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer
title_short The Pivotal Potentials of Scorpion Buthus Martensii Karsch-Analgesic-Antitumor Peptide in Pain Management and Cancer
title_sort pivotal potentials of scorpion buthus martensii karsch-analgesic-antitumor peptide in pain management and cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647755/
https://www.ncbi.nlm.nih.gov/pubmed/33178316
http://dx.doi.org/10.1155/2020/4234273
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