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Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms
Linezolid is an oxazolidinone class antibiotic used for treatment infections caused by various multidrug-resistant gram-positive pathogens including enterococci. However, recently, linezolid-resistant isolates in animals are considered as a human health hazard. In a broiler operation system, antimic...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647823/ https://www.ncbi.nlm.nih.gov/pubmed/33142524 http://dx.doi.org/10.1016/j.psj.2020.06.087 |
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author | Yoon, Sunghyun Kim, Yeong Bin Seo, Kwang Won Ha, Jong Su Noh, Eun Bi Lee, Young Ju |
author_facet | Yoon, Sunghyun Kim, Yeong Bin Seo, Kwang Won Ha, Jong Su Noh, Eun Bi Lee, Young Ju |
author_sort | Yoon, Sunghyun |
collection | PubMed |
description | Linezolid is an oxazolidinone class antibiotic used for treatment infections caused by various multidrug-resistant gram-positive pathogens including enterococci. However, recently, linezolid-resistant isolates in animals are considered as a human health hazard. In a broiler operation system, antimicrobial resistance can be transferred to the environment and commercial broiler via the fecal–oral route. Therefore, this study was conducted to investigate the prevalence and characteristics of linezolid-resistant Enterococcus faecalis (E. faecalis) from broiler parent stock in a broiler operation system. Among 297 E. faecalis isolates from 85 flocks in 8 broiler breeder farms, the prevalence of chloramphenicol- and linezolid-resistant isolates was 0 to 12.1% and 0 to 8.0%, respectively; however, there were no significant differences between farms. Therefore, a total of 14 (4.7%) chloramphenicol- and/or linezolid-resistant E. faecalis showed resistance to 7 or more antimicrobial classes. The drug-resistance gene optrA, which can confer resistance to linezolid, tedizolid, and phenicols, was found in 8 (2.69%) isolates, and 7 (2.36%) of the 8 optrA-positive isolates co-carried the phenicol exporter gene fexA. However, E. faecalis isolates from 3 of 8 broiler breeder farms only carried the optrA and/or fexA genes. As linezolid is one of the last antimicrobial treatments of choice for multidrug-resistant gram-positive pathogens including E. faecalis, the presence of antibiotic-resistant E. faecalis in broiler breeder farms should be monitored to prevent the introduction of linezolid-resistant strains to the food chain. |
format | Online Article Text |
id | pubmed-7647823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-76478232020-11-13 Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms Yoon, Sunghyun Kim, Yeong Bin Seo, Kwang Won Ha, Jong Su Noh, Eun Bi Lee, Young Ju Poult Sci Microbiology and Food Safety Linezolid is an oxazolidinone class antibiotic used for treatment infections caused by various multidrug-resistant gram-positive pathogens including enterococci. However, recently, linezolid-resistant isolates in animals are considered as a human health hazard. In a broiler operation system, antimicrobial resistance can be transferred to the environment and commercial broiler via the fecal–oral route. Therefore, this study was conducted to investigate the prevalence and characteristics of linezolid-resistant Enterococcus faecalis (E. faecalis) from broiler parent stock in a broiler operation system. Among 297 E. faecalis isolates from 85 flocks in 8 broiler breeder farms, the prevalence of chloramphenicol- and linezolid-resistant isolates was 0 to 12.1% and 0 to 8.0%, respectively; however, there were no significant differences between farms. Therefore, a total of 14 (4.7%) chloramphenicol- and/or linezolid-resistant E. faecalis showed resistance to 7 or more antimicrobial classes. The drug-resistance gene optrA, which can confer resistance to linezolid, tedizolid, and phenicols, was found in 8 (2.69%) isolates, and 7 (2.36%) of the 8 optrA-positive isolates co-carried the phenicol exporter gene fexA. However, E. faecalis isolates from 3 of 8 broiler breeder farms only carried the optrA and/or fexA genes. As linezolid is one of the last antimicrobial treatments of choice for multidrug-resistant gram-positive pathogens including E. faecalis, the presence of antibiotic-resistant E. faecalis in broiler breeder farms should be monitored to prevent the introduction of linezolid-resistant strains to the food chain. Elsevier 2020-08-15 /pmc/articles/PMC7647823/ /pubmed/33142524 http://dx.doi.org/10.1016/j.psj.2020.06.087 Text en © 2020 Published by Elsevier Inc. on behalf of Poultry Science Association Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Microbiology and Food Safety Yoon, Sunghyun Kim, Yeong Bin Seo, Kwang Won Ha, Jong Su Noh, Eun Bi Lee, Young Ju Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms |
title | Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms |
title_full | Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms |
title_fullStr | Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms |
title_full_unstemmed | Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms |
title_short | Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms |
title_sort | characteristics of linezolid-resistant enterococcus faecalis isolates from broiler breeder farms |
topic | Microbiology and Food Safety |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647823/ https://www.ncbi.nlm.nih.gov/pubmed/33142524 http://dx.doi.org/10.1016/j.psj.2020.06.087 |
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