Cargando…
Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial
INTRODUCTION: Mnemonic strategy training (MST) has been shown to improve cognitive performance and increase brain activation in those with mild cognitive impairment (MCI). However, little is known regarding the effects of MST on functional connectivity (FC) at rest. The aim of the present study was...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647944/ https://www.ncbi.nlm.nih.gov/pubmed/33204817 http://dx.doi.org/10.1002/trc2.12075 |
_version_ | 1783607014202540032 |
---|---|
author | Simon, Sharon Sanz Hampstead, Benjamin M. Nucci, Mariana P. Ferreira, Luiz Kobuti Duran, Fábio L. S. Fonseca, Luciana M. Martin, Maria da Graça M. Ávila, Renata Porto, Fábio H. G. Brucki, Sônia M. D. Martins, Camila B. Tascone, Lyssandra S. Jr., Edson Amaro Busatto, Geraldo F. Bottino, Cássio M. C. |
author_facet | Simon, Sharon Sanz Hampstead, Benjamin M. Nucci, Mariana P. Ferreira, Luiz Kobuti Duran, Fábio L. S. Fonseca, Luciana M. Martin, Maria da Graça M. Ávila, Renata Porto, Fábio H. G. Brucki, Sônia M. D. Martins, Camila B. Tascone, Lyssandra S. Jr., Edson Amaro Busatto, Geraldo F. Bottino, Cássio M. C. |
author_sort | Simon, Sharon Sanz |
collection | PubMed |
description | INTRODUCTION: Mnemonic strategy training (MST) has been shown to improve cognitive performance and increase brain activation in those with mild cognitive impairment (MCI). However, little is known regarding the effects of MST on functional connectivity (FC) at rest. The aim of the present study was to investigate the MST focused on face‐name associations effect on resting‐state FC in those with MCI METHODS: Twenty‐six amnestic MCI participants were randomized in MST (N = 14) and Education Program (active control; N = 12). Interventions occurred twice a week over two consecutive weeks (ie, four sessions). Resting‐state functional magnetic resonance imaging was collected at pre‐ and post‐intervention. Regions of interest (ROIs) were selected based on areas that previously showed task‐related activation changes after MST. Changes were examined through ROI‐to‐ROI analysis and significant results were corrected for multiple comparisons. RESULTS: At post‐intervention, only the MST group showed increased FC, whereas the control group showed decreased or no change in FC. After MST, there was an increased FC between the left middle temporal gyrus and right orbitofrontal cortex. In addition, a time‐by‐group interaction indicated that the MST group showed greater increased FC between the right inferior frontal gyrus and left brain regions, such as fusiform gyrus, temporal pole, and orbitofrontal cortex relative to controls. DISCUSSION: MST enhanced FC in regions that are functionally relevant for the training; however, not in all ROIs investigated. Our findings suggest that MST‐induced changes are reflected in task‐specific conditions, as previously reported, but also in general innate connectivity. Our results both enhance knowledge about the mechanisms underlying MST effects and may provide neurophysiological evidence of training transfer. |
format | Online Article Text |
id | pubmed-7647944 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76479442020-11-16 Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial Simon, Sharon Sanz Hampstead, Benjamin M. Nucci, Mariana P. Ferreira, Luiz Kobuti Duran, Fábio L. S. Fonseca, Luciana M. Martin, Maria da Graça M. Ávila, Renata Porto, Fábio H. G. Brucki, Sônia M. D. Martins, Camila B. Tascone, Lyssandra S. Jr., Edson Amaro Busatto, Geraldo F. Bottino, Cássio M. C. Alzheimers Dement (N Y) Research Articles INTRODUCTION: Mnemonic strategy training (MST) has been shown to improve cognitive performance and increase brain activation in those with mild cognitive impairment (MCI). However, little is known regarding the effects of MST on functional connectivity (FC) at rest. The aim of the present study was to investigate the MST focused on face‐name associations effect on resting‐state FC in those with MCI METHODS: Twenty‐six amnestic MCI participants were randomized in MST (N = 14) and Education Program (active control; N = 12). Interventions occurred twice a week over two consecutive weeks (ie, four sessions). Resting‐state functional magnetic resonance imaging was collected at pre‐ and post‐intervention. Regions of interest (ROIs) were selected based on areas that previously showed task‐related activation changes after MST. Changes were examined through ROI‐to‐ROI analysis and significant results were corrected for multiple comparisons. RESULTS: At post‐intervention, only the MST group showed increased FC, whereas the control group showed decreased or no change in FC. After MST, there was an increased FC between the left middle temporal gyrus and right orbitofrontal cortex. In addition, a time‐by‐group interaction indicated that the MST group showed greater increased FC between the right inferior frontal gyrus and left brain regions, such as fusiform gyrus, temporal pole, and orbitofrontal cortex relative to controls. DISCUSSION: MST enhanced FC in regions that are functionally relevant for the training; however, not in all ROIs investigated. Our findings suggest that MST‐induced changes are reflected in task‐specific conditions, as previously reported, but also in general innate connectivity. Our results both enhance knowledge about the mechanisms underlying MST effects and may provide neurophysiological evidence of training transfer. John Wiley and Sons Inc. 2020-11-06 /pmc/articles/PMC7647944/ /pubmed/33204817 http://dx.doi.org/10.1002/trc2.12075 Text en © 2020 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Simon, Sharon Sanz Hampstead, Benjamin M. Nucci, Mariana P. Ferreira, Luiz Kobuti Duran, Fábio L. S. Fonseca, Luciana M. Martin, Maria da Graça M. Ávila, Renata Porto, Fábio H. G. Brucki, Sônia M. D. Martins, Camila B. Tascone, Lyssandra S. Jr., Edson Amaro Busatto, Geraldo F. Bottino, Cássio M. C. Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial |
title | Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial |
title_full | Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial |
title_fullStr | Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial |
title_full_unstemmed | Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial |
title_short | Mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: Results from a randomized controlled trial |
title_sort | mnemonic strategy training modulates functional connectivity at rest in mild cognitive impairment: results from a randomized controlled trial |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647944/ https://www.ncbi.nlm.nih.gov/pubmed/33204817 http://dx.doi.org/10.1002/trc2.12075 |
work_keys_str_mv | AT simonsharonsanz mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT hampsteadbenjaminm mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT nuccimarianap mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT ferreiraluizkobuti mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT duranfabiols mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT fonsecalucianam mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT martinmariadagracam mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT avilarenata mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT portofabiohg mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT bruckisoniamd mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT martinscamilab mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT tasconelyssandras mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT jredsonamaro mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT busattogeraldof mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial AT bottinocassiomc mnemonicstrategytrainingmodulatesfunctionalconnectivityatrestinmildcognitiveimpairmentresultsfromarandomizedcontrolledtrial |