Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse‐induced median mononeuropathy

Encapsulation of median nerves is a hallmark of overuse‐induced median mononeuropathy and contributes to functional declines. We tested if an antibody against CTGF/CCN2 (termed FG‐3019 or Pamrevlumab) reduces established neural fibrosis and sensorimotor declines in a clinically relevant rodent model...

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Detalles Bibliográficos
Autores principales: Barbe, Mary F., Hilliard, Brendan A., Amin, Mamta, Harris, Michele Y., Hobson, Lucas J., Cruz, Geneva E., Dorotan, Jocelynne T., Paul, Ryan W., Klyne, David M., Popoff, Steven N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
RESEARCH ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647961/
https://www.ncbi.nlm.nih.gov/pubmed/32379362
http://dx.doi.org/10.1002/jor.24709

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