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Mapping the epigenetic modifications of DNA and RNA
Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biologica...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Higher Education Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647981/ https://www.ncbi.nlm.nih.gov/pubmed/32440736 http://dx.doi.org/10.1007/s13238-020-00733-7 |
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author | Zhao, Lin-Yong Song, Jinghui Liu, Yibin Song, Chun-Xiao Yi, Chengqi |
author_facet | Zhao, Lin-Yong Song, Jinghui Liu, Yibin Song, Chun-Xiao Yi, Chengqi |
author_sort | Zhao, Lin-Yong |
collection | PubMed |
description | Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study. Here, we review the recent technological advances in this rapidly evolving field. We focus on high-throughput detection methods and biological findings for these modifications, and discuss questions to be addressed as well. We also summarize third-generation sequencing methods, which enable long-read and single-molecule sequencing of DNA and RNA modification. |
format | Online Article Text |
id | pubmed-7647981 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Higher Education Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-76479812020-11-10 Mapping the epigenetic modifications of DNA and RNA Zhao, Lin-Yong Song, Jinghui Liu, Yibin Song, Chun-Xiao Yi, Chengqi Protein Cell Review Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study. Here, we review the recent technological advances in this rapidly evolving field. We focus on high-throughput detection methods and biological findings for these modifications, and discuss questions to be addressed as well. We also summarize third-generation sequencing methods, which enable long-read and single-molecule sequencing of DNA and RNA modification. Higher Education Press 2020-05-22 2020-11 /pmc/articles/PMC7647981/ /pubmed/32440736 http://dx.doi.org/10.1007/s13238-020-00733-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Zhao, Lin-Yong Song, Jinghui Liu, Yibin Song, Chun-Xiao Yi, Chengqi Mapping the epigenetic modifications of DNA and RNA |
title | Mapping the epigenetic modifications of DNA and RNA |
title_full | Mapping the epigenetic modifications of DNA and RNA |
title_fullStr | Mapping the epigenetic modifications of DNA and RNA |
title_full_unstemmed | Mapping the epigenetic modifications of DNA and RNA |
title_short | Mapping the epigenetic modifications of DNA and RNA |
title_sort | mapping the epigenetic modifications of dna and rna |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647981/ https://www.ncbi.nlm.nih.gov/pubmed/32440736 http://dx.doi.org/10.1007/s13238-020-00733-7 |
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