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Cortical 3-hinges could serve as hubs in cortico-cortical connective network

Mapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the c...

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Autores principales: Zhang, Tuo, Li, Xiao, Jiang, Xi, Ge, Fangfei, Zhang, Shu, Zhao, Lin, Liu, Huan, Huang, Ying, Wang, Xianqiao, Yang, Jian, Guo, Lei, Hu, Xiaoping, Liu, Tianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647986/
https://www.ncbi.nlm.nih.gov/pubmed/31950404
http://dx.doi.org/10.1007/s11682-019-00204-6
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author Zhang, Tuo
Li, Xiao
Jiang, Xi
Ge, Fangfei
Zhang, Shu
Zhao, Lin
Liu, Huan
Huang, Ying
Wang, Xianqiao
Yang, Jian
Guo, Lei
Hu, Xiaoping
Liu, Tianming
author_facet Zhang, Tuo
Li, Xiao
Jiang, Xi
Ge, Fangfei
Zhang, Shu
Zhao, Lin
Liu, Huan
Huang, Ying
Wang, Xianqiao
Yang, Jian
Guo, Lei
Hu, Xiaoping
Liu, Tianming
author_sort Zhang, Tuo
collection PubMed
description Mapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the conjunction of three gyral crests. The uniqueness of the 3-hinge was evidenced by its thicker cortex and stronger fiber connections than other gyral regions. However, the role that 3-hinges play in cortico-cortical connective architecture remains unclear. To this end, we conducted MRI studies by constructing structural cortico-cortical connective networks based on a fine-granular cortical parcellation, the parcels of which were automatically labeled as 3-hinge, 2-hinge (ordinary gyrus) or sulcus. On human brains, 3-hinges possess significantly higher degrees, strengths and betweennesses than 2-hinges, suggesting that 3-hinges could serve more like hubs in the cortico-cortical connective network. This hypothesis gains supports from human functional network analyses, in which 3-hinges are involved in more global functional networks than ordinary gyri. In addition, 3-hinges could serve as ‘connector’ hubs rather than ‘provincial’ hubs and they account for a dominant proportion of nodes in the high-level ‘backbone’ of the network. These structural results are reproduced on chimpanzee and macaque brains, while the roles of 3-hinges as hubs become more pronounced in higher order primates. Our new findings could provide a new window to the relation between cortical convolution, anatomical connection and brain function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11682-019-00204-6) contains supplementary material, which is available to authorized users.
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spelling pubmed-76479862020-11-10 Cortical 3-hinges could serve as hubs in cortico-cortical connective network Zhang, Tuo Li, Xiao Jiang, Xi Ge, Fangfei Zhang, Shu Zhao, Lin Liu, Huan Huang, Ying Wang, Xianqiao Yang, Jian Guo, Lei Hu, Xiaoping Liu, Tianming Brain Imaging Behav Original Research Mapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the conjunction of three gyral crests. The uniqueness of the 3-hinge was evidenced by its thicker cortex and stronger fiber connections than other gyral regions. However, the role that 3-hinges play in cortico-cortical connective architecture remains unclear. To this end, we conducted MRI studies by constructing structural cortico-cortical connective networks based on a fine-granular cortical parcellation, the parcels of which were automatically labeled as 3-hinge, 2-hinge (ordinary gyrus) or sulcus. On human brains, 3-hinges possess significantly higher degrees, strengths and betweennesses than 2-hinges, suggesting that 3-hinges could serve more like hubs in the cortico-cortical connective network. This hypothesis gains supports from human functional network analyses, in which 3-hinges are involved in more global functional networks than ordinary gyri. In addition, 3-hinges could serve as ‘connector’ hubs rather than ‘provincial’ hubs and they account for a dominant proportion of nodes in the high-level ‘backbone’ of the network. These structural results are reproduced on chimpanzee and macaque brains, while the roles of 3-hinges as hubs become more pronounced in higher order primates. Our new findings could provide a new window to the relation between cortical convolution, anatomical connection and brain function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11682-019-00204-6) contains supplementary material, which is available to authorized users. Springer US 2020-01-16 2020 /pmc/articles/PMC7647986/ /pubmed/31950404 http://dx.doi.org/10.1007/s11682-019-00204-6 Text en © The Author(s) 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Research
Zhang, Tuo
Li, Xiao
Jiang, Xi
Ge, Fangfei
Zhang, Shu
Zhao, Lin
Liu, Huan
Huang, Ying
Wang, Xianqiao
Yang, Jian
Guo, Lei
Hu, Xiaoping
Liu, Tianming
Cortical 3-hinges could serve as hubs in cortico-cortical connective network
title Cortical 3-hinges could serve as hubs in cortico-cortical connective network
title_full Cortical 3-hinges could serve as hubs in cortico-cortical connective network
title_fullStr Cortical 3-hinges could serve as hubs in cortico-cortical connective network
title_full_unstemmed Cortical 3-hinges could serve as hubs in cortico-cortical connective network
title_short Cortical 3-hinges could serve as hubs in cortico-cortical connective network
title_sort cortical 3-hinges could serve as hubs in cortico-cortical connective network
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647986/
https://www.ncbi.nlm.nih.gov/pubmed/31950404
http://dx.doi.org/10.1007/s11682-019-00204-6
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