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Cortical 3-hinges could serve as hubs in cortico-cortical connective network
Mapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the c...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647986/ https://www.ncbi.nlm.nih.gov/pubmed/31950404 http://dx.doi.org/10.1007/s11682-019-00204-6 |
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author | Zhang, Tuo Li, Xiao Jiang, Xi Ge, Fangfei Zhang, Shu Zhao, Lin Liu, Huan Huang, Ying Wang, Xianqiao Yang, Jian Guo, Lei Hu, Xiaoping Liu, Tianming |
author_facet | Zhang, Tuo Li, Xiao Jiang, Xi Ge, Fangfei Zhang, Shu Zhao, Lin Liu, Huan Huang, Ying Wang, Xianqiao Yang, Jian Guo, Lei Hu, Xiaoping Liu, Tianming |
author_sort | Zhang, Tuo |
collection | PubMed |
description | Mapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the conjunction of three gyral crests. The uniqueness of the 3-hinge was evidenced by its thicker cortex and stronger fiber connections than other gyral regions. However, the role that 3-hinges play in cortico-cortical connective architecture remains unclear. To this end, we conducted MRI studies by constructing structural cortico-cortical connective networks based on a fine-granular cortical parcellation, the parcels of which were automatically labeled as 3-hinge, 2-hinge (ordinary gyrus) or sulcus. On human brains, 3-hinges possess significantly higher degrees, strengths and betweennesses than 2-hinges, suggesting that 3-hinges could serve more like hubs in the cortico-cortical connective network. This hypothesis gains supports from human functional network analyses, in which 3-hinges are involved in more global functional networks than ordinary gyri. In addition, 3-hinges could serve as ‘connector’ hubs rather than ‘provincial’ hubs and they account for a dominant proportion of nodes in the high-level ‘backbone’ of the network. These structural results are reproduced on chimpanzee and macaque brains, while the roles of 3-hinges as hubs become more pronounced in higher order primates. Our new findings could provide a new window to the relation between cortical convolution, anatomical connection and brain function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11682-019-00204-6) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7647986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-76479862020-11-10 Cortical 3-hinges could serve as hubs in cortico-cortical connective network Zhang, Tuo Li, Xiao Jiang, Xi Ge, Fangfei Zhang, Shu Zhao, Lin Liu, Huan Huang, Ying Wang, Xianqiao Yang, Jian Guo, Lei Hu, Xiaoping Liu, Tianming Brain Imaging Behav Original Research Mapping the relation between cortical convolution and structural/functional brain architectures could provide deep insights into the mechanisms of brain development, evolution and diseases. In our previous studies, we found a unique gyral folding pattern, termed a 3-hinge, which was defined as the conjunction of three gyral crests. The uniqueness of the 3-hinge was evidenced by its thicker cortex and stronger fiber connections than other gyral regions. However, the role that 3-hinges play in cortico-cortical connective architecture remains unclear. To this end, we conducted MRI studies by constructing structural cortico-cortical connective networks based on a fine-granular cortical parcellation, the parcels of which were automatically labeled as 3-hinge, 2-hinge (ordinary gyrus) or sulcus. On human brains, 3-hinges possess significantly higher degrees, strengths and betweennesses than 2-hinges, suggesting that 3-hinges could serve more like hubs in the cortico-cortical connective network. This hypothesis gains supports from human functional network analyses, in which 3-hinges are involved in more global functional networks than ordinary gyri. In addition, 3-hinges could serve as ‘connector’ hubs rather than ‘provincial’ hubs and they account for a dominant proportion of nodes in the high-level ‘backbone’ of the network. These structural results are reproduced on chimpanzee and macaque brains, while the roles of 3-hinges as hubs become more pronounced in higher order primates. Our new findings could provide a new window to the relation between cortical convolution, anatomical connection and brain function. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11682-019-00204-6) contains supplementary material, which is available to authorized users. Springer US 2020-01-16 2020 /pmc/articles/PMC7647986/ /pubmed/31950404 http://dx.doi.org/10.1007/s11682-019-00204-6 Text en © The Author(s) 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Research Zhang, Tuo Li, Xiao Jiang, Xi Ge, Fangfei Zhang, Shu Zhao, Lin Liu, Huan Huang, Ying Wang, Xianqiao Yang, Jian Guo, Lei Hu, Xiaoping Liu, Tianming Cortical 3-hinges could serve as hubs in cortico-cortical connective network |
title | Cortical 3-hinges could serve as hubs in cortico-cortical connective network |
title_full | Cortical 3-hinges could serve as hubs in cortico-cortical connective network |
title_fullStr | Cortical 3-hinges could serve as hubs in cortico-cortical connective network |
title_full_unstemmed | Cortical 3-hinges could serve as hubs in cortico-cortical connective network |
title_short | Cortical 3-hinges could serve as hubs in cortico-cortical connective network |
title_sort | cortical 3-hinges could serve as hubs in cortico-cortical connective network |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7647986/ https://www.ncbi.nlm.nih.gov/pubmed/31950404 http://dx.doi.org/10.1007/s11682-019-00204-6 |
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