UDP‐glucuronosyltransferase polymorphisms affect diethylnitrosamine‐induced carcinogenesis in humanized transgenic mice

UDP‐glucuronosyltransferase (UGT) 1A enzymes detoxify a broad array of exogenous compounds including environmental toxins and carcinogens. Case‐control studies identified genetic variations in UGT1A genes leading to reduced glucuronidation activity, which were associated with hepatocellular carcinom...

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Detalles Bibliográficos
Autores principales: Landerer, Steffen, Kalthoff, Sandra, Paulusch, Stefan, Strassburg, Christian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648041/
https://www.ncbi.nlm.nih.gov/pubmed/32860300
http://dx.doi.org/10.1111/cas.14635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648041/
https://www.ncbi.nlm.nih.gov/pubmed/32860300
http://dx.doi.org/10.1111/cas.14635

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