Translational study of the whole transcriptome in rats and genetic polymorphisms in humans identifies LRP1B and VPS13A as key genes involved in tolerance to cocaine-induced motor disturbances

Motor disturbances strongly increase the burden of cocaine use disorder (CUDs). The objective of our translational study was to identify the genes and biological pathways underlying the tolerance to cocaine-induced motor effects. In a 5-day protocol measuring motor tolerance to cocaine in rats (N = ...

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Detalles Bibliográficos
Autores principales: Vorspan, Florence, Icick, Romain, Mekdad, Nawel, Courtin, Cindie, Bloch, Vanessa, Bellivier, Frank, Laplanche, Jean-Louis, Prince, Nathalie, Pishalin, Dmitry, Firmo, Cyril, Blugeon, Corinne, Mégarbane, Bruno, Marie-Claire, Cynthia, Benturquia, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648099/
https://www.ncbi.nlm.nih.gov/pubmed/33159041
http://dx.doi.org/10.1038/s41398-020-01050-7

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