Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities

Enzyme orthologs sharing identical primary functions can have different promiscuous activities. While it is possible to mine this natural diversity to obtain useful biocatalysts, generating comparably rich ortholog diversity is difficult, as it is the product of deep evolutionary processes occurring...

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Detalles Bibliográficos
Autores principales: Rix, Gordon, Watkins-Dulaney, Ella J., Almhjell, Patrick J., Boville, Christina E., Arnold, Frances H., Liu, Chang C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648111/
https://www.ncbi.nlm.nih.gov/pubmed/33159067
http://dx.doi.org/10.1038/s41467-020-19539-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648111/
https://www.ncbi.nlm.nih.gov/pubmed/33159067
http://dx.doi.org/10.1038/s41467-020-19539-6

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