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Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities
Enzyme orthologs sharing identical primary functions can have different promiscuous activities. While it is possible to mine this natural diversity to obtain useful biocatalysts, generating comparably rich ortholog diversity is difficult, as it is the product of deep evolutionary processes occurring...
Autores principales: | Rix, Gordon, Watkins-Dulaney, Ella J., Almhjell, Patrick J., Boville, Christina E., Arnold, Frances H., Liu, Chang C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648111/ https://www.ncbi.nlm.nih.gov/pubmed/33159067 http://dx.doi.org/10.1038/s41467-020-19539-6 |
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