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The roles of the gut microbiota–miRNA interaction in the host pathophysiology

The gut microbiota regulates the biological processes of organisms acting like ‘another’ genome, affecting the health and disease of the host. MicroRNAs, as important physiological regulators, have been found to be involved in health and disease. Recently, the gut microbiota has been reported to aff...

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Autores principales: Li, Meihong, Chen, Wei-Dong, Wang, Yan-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648389/
https://www.ncbi.nlm.nih.gov/pubmed/33160314
http://dx.doi.org/10.1186/s10020-020-00234-7
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author Li, Meihong
Chen, Wei-Dong
Wang, Yan-Dong
author_facet Li, Meihong
Chen, Wei-Dong
Wang, Yan-Dong
author_sort Li, Meihong
collection PubMed
description The gut microbiota regulates the biological processes of organisms acting like ‘another’ genome, affecting the health and disease of the host. MicroRNAs, as important physiological regulators, have been found to be involved in health and disease. Recently, the gut microbiota has been reported to affect host health by regulating host miRNAs. For example, Fusobacterium nucleatum could aggravate chemoresistance of colorectal cancer by decreasing the expression of miR-18a* and miR-4802. What’s more, miRNAs can shape the gut microbiota composition, ultimately affecting the host's physiology and disease. miR-515-5p and miR-1226-5p could promote the growth of Fusobacterium nucleatum (Fn) and Escherichia coli (E.coli), which have been reported to drive colorectal cancer. Here, we will review current findings of the interactions between the gut microbiota and microRNAs and discuss how the gut microbiota–microRNA interactions affect host pathophysiology including intestinal, neurological, cardiovascular, and immune health and diseases.
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spelling pubmed-76483892020-11-09 The roles of the gut microbiota–miRNA interaction in the host pathophysiology Li, Meihong Chen, Wei-Dong Wang, Yan-Dong Mol Med Mini-Review The gut microbiota regulates the biological processes of organisms acting like ‘another’ genome, affecting the health and disease of the host. MicroRNAs, as important physiological regulators, have been found to be involved in health and disease. Recently, the gut microbiota has been reported to affect host health by regulating host miRNAs. For example, Fusobacterium nucleatum could aggravate chemoresistance of colorectal cancer by decreasing the expression of miR-18a* and miR-4802. What’s more, miRNAs can shape the gut microbiota composition, ultimately affecting the host's physiology and disease. miR-515-5p and miR-1226-5p could promote the growth of Fusobacterium nucleatum (Fn) and Escherichia coli (E.coli), which have been reported to drive colorectal cancer. Here, we will review current findings of the interactions between the gut microbiota and microRNAs and discuss how the gut microbiota–microRNA interactions affect host pathophysiology including intestinal, neurological, cardiovascular, and immune health and diseases. BioMed Central 2020-11-07 /pmc/articles/PMC7648389/ /pubmed/33160314 http://dx.doi.org/10.1186/s10020-020-00234-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Mini-Review
Li, Meihong
Chen, Wei-Dong
Wang, Yan-Dong
The roles of the gut microbiota–miRNA interaction in the host pathophysiology
title The roles of the gut microbiota–miRNA interaction in the host pathophysiology
title_full The roles of the gut microbiota–miRNA interaction in the host pathophysiology
title_fullStr The roles of the gut microbiota–miRNA interaction in the host pathophysiology
title_full_unstemmed The roles of the gut microbiota–miRNA interaction in the host pathophysiology
title_short The roles of the gut microbiota–miRNA interaction in the host pathophysiology
title_sort roles of the gut microbiota–mirna interaction in the host pathophysiology
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648389/
https://www.ncbi.nlm.nih.gov/pubmed/33160314
http://dx.doi.org/10.1186/s10020-020-00234-7
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