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Enhanced antitumor effects of follicle-stimulating hormone receptor-mediated hexokinase-2 depletion on ovarian cancer mediated by a shift in glucose metabolism

BACKGROUND: Most cancers favor glycolytic-based glucose metabolism. Hexokinase-2 (HK2), the first glycolytic rate-limiting enzyme, shows limited expression in normal adult tissues but is overexpressed in many tumor tissues, including ovarian cancer. HK2 has been shown to be correlated with the progr...

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Detalles Bibliográficos
Autores principales:	Zhang, Meng, Liu, Qiyu, Zhang, Mingxing, Cao, Cong, Liu, Xiaoxia, Zhang, Mengyu, Li, Guiling, Xu, Congjian, Zhang, Xiaoyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648390/ https://www.ncbi.nlm.nih.gov/pubmed/33160373 http://dx.doi.org/10.1186/s12951-020-00720-4

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