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Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment

BACKGROUND: The Reelin (RELN) gene encodes the protein reelin, which is a large extracellular matrix glycoprotein that plays a key role in brain development. Additionally, this protein may be involved in memory formation, neurotransmission, and synaptic plasticity, which have been shown to be disrup...

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Autores principales: Yin, Jiajun, Lu, Yana, Yu, Shui, Dai, Zhanzhan, Zhang, Fuquan, Yuan, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648395/
https://www.ncbi.nlm.nih.gov/pubmed/33158463
http://dx.doi.org/10.1186/s41065-020-00158-6
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author Yin, Jiajun
Lu, Yana
Yu, Shui
Dai, Zhanzhan
Zhang, Fuquan
Yuan, Jianmin
author_facet Yin, Jiajun
Lu, Yana
Yu, Shui
Dai, Zhanzhan
Zhang, Fuquan
Yuan, Jianmin
author_sort Yin, Jiajun
collection PubMed
description BACKGROUND: The Reelin (RELN) gene encodes the protein reelin, which is a large extracellular matrix glycoprotein that plays a key role in brain development. Additionally, this protein may be involved in memory formation, neurotransmission, and synaptic plasticity, which have been shown to be disrupted in schizophrenia (SCZ). A decreasing trend in the expression of RELN mRNA in the brain and peripheral blood of SCZ patients has been observed. There is a need to determine whether changes in RELN mRNA expression in SCZ patients are the result of long-term antipsychotic treatment rather than the etiological characteristics of schizophrenia. The expression levels of RELN mRNA in the peripheral blood of 48 healthy controls and 30 SCZ patients before and after 12-weeks of treatment were measured using quantitative real-time PCR. RESULTS: The expression levels of RELN mRNA in the SCZ group were significantly lower than that of healthy controls; however, after 12-weeks of antipsychotic treatment, RELN mRNA levels were significantly increased in the SCZ group. CONCLUSION: The up-regulation of RELN mRNA expression was current in SCZ patients after antipsychotic treatment, suggesting that the changes in RELN mRNA expression were related to the effect of the antipsychotic treatment.
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spelling pubmed-76483952020-11-09 Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment Yin, Jiajun Lu, Yana Yu, Shui Dai, Zhanzhan Zhang, Fuquan Yuan, Jianmin Hereditas Research BACKGROUND: The Reelin (RELN) gene encodes the protein reelin, which is a large extracellular matrix glycoprotein that plays a key role in brain development. Additionally, this protein may be involved in memory formation, neurotransmission, and synaptic plasticity, which have been shown to be disrupted in schizophrenia (SCZ). A decreasing trend in the expression of RELN mRNA in the brain and peripheral blood of SCZ patients has been observed. There is a need to determine whether changes in RELN mRNA expression in SCZ patients are the result of long-term antipsychotic treatment rather than the etiological characteristics of schizophrenia. The expression levels of RELN mRNA in the peripheral blood of 48 healthy controls and 30 SCZ patients before and after 12-weeks of treatment were measured using quantitative real-time PCR. RESULTS: The expression levels of RELN mRNA in the SCZ group were significantly lower than that of healthy controls; however, after 12-weeks of antipsychotic treatment, RELN mRNA levels were significantly increased in the SCZ group. CONCLUSION: The up-regulation of RELN mRNA expression was current in SCZ patients after antipsychotic treatment, suggesting that the changes in RELN mRNA expression were related to the effect of the antipsychotic treatment. BioMed Central 2020-11-06 /pmc/articles/PMC7648395/ /pubmed/33158463 http://dx.doi.org/10.1186/s41065-020-00158-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Yin, Jiajun
Lu, Yana
Yu, Shui
Dai, Zhanzhan
Zhang, Fuquan
Yuan, Jianmin
Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment
title Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment
title_full Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment
title_fullStr Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment
title_full_unstemmed Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment
title_short Exploring the mRNA expression level of RELN in peripheral blood of schizophrenia patients before and after antipsychotic treatment
title_sort exploring the mrna expression level of reln in peripheral blood of schizophrenia patients before and after antipsychotic treatment
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648395/
https://www.ncbi.nlm.nih.gov/pubmed/33158463
http://dx.doi.org/10.1186/s41065-020-00158-6
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