Optogenetic Control Reveals Differential Promoter Interpretation of Transcription Factor Nuclear Translocation Dynamics

Gene expression is thought to be affected not only by the concentration of transcription factors (TFs) but also the dynamics of their nuclear translocation. Testing this hypothesis requires direct control of TF dynamics. Here, we engineer CLASP, an optogenetic tool for rapid and tunable translocatio...

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Detalles Bibliográficos
Autores principales: Chen, Susan Y., Osimiri, Lindsey C., Chevalier, Michael, Bugaj, Lukasz J., Nguyen, Taylor H., Greenstein, R.A., Ng, Andrew H., Stewart-Ornstein, Jacob, Neves, Lauren T., El-Samad, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648432/
https://www.ncbi.nlm.nih.gov/pubmed/32898473
http://dx.doi.org/10.1016/j.cels.2020.08.009

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