Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor performance in ALS SOD1(G93A) female mice

Neuroinflammation is one of the main physiopathological mechanisms of amyotrophic lateral sclerosis (ALS), produced by the chronic activation of microglia in the CNS. This process is triggered by the persistent activation of the ATP-gated P2X7 receptor (P2RX7, hereafter referred to as P2X7R). The pr...

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Detalles Bibliográficos
Autores principales: Ruiz-Ruiz, Cristina, García-Magro, Nuria, Negredo, Pilar, Avendaño, Carlos, Bhattacharya, Anindya, Ceusters, Marc, García, Antonio G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648608/
https://www.ncbi.nlm.nih.gov/pubmed/33174532
http://dx.doi.org/10.1242/dmm.045732

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