mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline

Lymphangioleiomyomatosis (LAM) is a rare fatal cystic lung disease due to bi-allelic inactivating mutations in tuberous sclerosis complex (TSC1/TSC2) genes coding for suppressors of the mechanistic target of rapamycin complex 1 (mTORC1). The origin of LAM cells is still unknown. Here, we profile a L...

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Detalles Bibliográficos
Autores principales: Obraztsova, Kseniya, Basil, Maria C., Rue, Ryan, Sivakumar, Aravind, Lin, Susan M., Mukhitov, Alexander R., Gritsiuta, Andrei I., Evans, Jilly F., Kopp, Meghan, Katzen, Jeremy, Robichaud, Annette, Atochina-Vasserman, Elena N., Li, Shanru, Carl, Justine, Babu, Apoorva, Morley, Michael P., Cantu, Edward, Beers, Michael F., Frank, David B., Morrisey, Edward E., Krymskaya, Vera P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648630/
https://www.ncbi.nlm.nih.gov/pubmed/33159078
http://dx.doi.org/10.1038/s41467-020-18979-4

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