PD-L1 degradation pathway and immunotherapy for cancer

Programmed death ligand 1 (PD-L1, CD274) is an essential immune checkpoint protein that binds to programmed death 1 (PD-1) on T-lymphocytes. T cell plays a critical role in killing cancer cells while the cancer cell exhibits immune escape by the expression of PD-L1. The binding of PD-L1 to PD-1 inhi...

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Detalles Bibliográficos
Autores principales: Gou, Qian, Dong, Chen, Xu, Huihui, Khan, Bibimaryam, Jin, Jianhua, Liu, Qian, Shi, Juanjuan, Hou, Yongzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648632/
https://www.ncbi.nlm.nih.gov/pubmed/33159034
http://dx.doi.org/10.1038/s41419-020-03140-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648632/
https://www.ncbi.nlm.nih.gov/pubmed/33159034
http://dx.doi.org/10.1038/s41419-020-03140-2

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