Cargando…

Discovery of multiple anti-CRISPRs highlights anti-defense gene clustering in mobile genetic elements

Many prokaryotes employ CRISPR–Cas systems to combat invading mobile genetic elements (MGEs). In response, some MGEs have developed strategies to bypass immunity, including anti-CRISPR (Acr) proteins; yet the diversity, distribution and spectrum of activity of this immune evasion strategy remain lar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pinilla-Redondo, Rafael, Shehreen, Saadlee, Marino, Nicole D., Fagerlund, Robert D., Brown, Chris M., Sørensen, Søren J., Fineran, Peter C., Bondy-Denomy, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648647/ https://www.ncbi.nlm.nih.gov/pubmed/33159058 http://dx.doi.org/10.1038/s41467-020-19415-3

Ejemplares similares

Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins
por: Shehreen, Saadlee, et al.
Publicado: (2022)

Bacteriophages suppress CRISPR–Cas immunity using RNA-based anti-CRISPRs
por: Camara-Wilpert, Sarah, et al.
Publicado: (2023)

Mobile element warfare via CRISPR and anti-CRISPR in Pseudomonas aeruginosa
por: León, Lina M, et al.
Publicado: (2021)

CRISPR-Cas12a targeting of ssDNA plays no detectable role in immunity
por: Marino, Nicole D, et al.
Publicado: (2022)

Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer
por: Mahendra, Caroline, et al.
Publicado: (2020)

The autoregulator Aca2 mediates anti-CRISPR repression
por: Birkholz, Nils, et al.
Publicado: (2019)

The solution structure of an anti-CRISPR protein
por: Maxwell, Karen L., et al.
Publicado: (2016)

CRISPR-Cas systems are widespread accessory elements across bacterial and archaeal plasmids
por: Pinilla-Redondo, Rafael, et al.
Publicado: (2021)

Core defense hotspots within Pseudomonas aeruginosa are a consistent and rich source of anti-phage defense systems
por: Johnson, Matthew C, et al.
Publicado: (2023)

Crystal structure of the anti-CRISPR repressor Aca2
por: Usher, Ben, et al.
Publicado: (2021)

A New Group of Phage Anti-CRISPR Genes Inhibits the Type I-E CRISPR-Cas System of Pseudomonas aeruginosa
por: Pawluk, April, et al.
Publicado: (2014)

Disabling Cas9 by an anti-CRISPR DNA mimic
por: Shin, Jiyung, et al.
Publicado: (2017)

Machine-learning approach expands the repertoire of anti-CRISPR protein families
por: Gussow, Ayal B., et al.
Publicado: (2020)

The Cpf1 CRISPR-Cas protein expands genome-editing tools
por: Fagerlund, Robert D., et al.
Publicado: (2015)

Anti-CRISPR-mediated control of gene editing and synthetic circuits in eukaryotic cells
por: Nakamura, Muneaki, et al.
Publicado: (2019)

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system
por: Bondy-Denomy, Joe, et al.
Publicado: (2012)

Molecular basis of anti-CRISPR operon repression by Aca10
por: Lee, So Yeon, et al.
Publicado: (2022)

Contribution of target alteration, protection and efflux pump in achieving high ciprofloxacin resistance in Enterobacteriaceae
por: Chakrabarty, Ram Prosad, et al.
Publicado: (2016)

The biology and type I/III hybrid nature of type I-D CRISPR–Cas systems
por: McBride, Tess M., et al.
Publicado: (2023)

Aspartame, acesulfame K and sucralose- influence on the metabolism of Escherichia coli
por: Shahriar, Shayan, et al.
Publicado: (2020)

Bacterial alginate regulators and phage homologs repress CRISPR-Cas immunity
por: Borges, Adair L., et al.
Publicado: (2020)

Active and adaptive Legionella CRISPR‐Cas reveals a recurrent challenge to the pathogen
por: Rao, Chitong, et al.
Publicado: (2016)

Positioning Diverse Type IV Structures and Functions Within Class 1 CRISPR-Cas Systems
por: Taylor, Hannah N., et al.
Publicado: (2021)

Molecular basis of dual anti-CRISPR and auto-regulatory functions of AcrIF24
por: Kim, Gi Eob, et al.
Publicado: (2022)

A mobile restriction–modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease
por: Birkholz, Nils, et al.
Publicado: (2022)

A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases
por: Mendoza, Senén D., et al.
Publicado: (2019)

Intracellular Organization by Jumbo Bacteriophages
por: Guan, Jingwen, et al.
Publicado: (2020)

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
por: Cao, Xueli, et al.
Publicado: (2023)

Type IV CRISPR–Cas systems are highly diverse and involved in competition between plasmids
por: Pinilla-Redondo, Rafael, et al.
Publicado: (2020)

Top-Down Proteomics of Human Saliva Highlights Anti-inflammatory, Antioxidant, and Antimicrobial Defense Responses in Alzheimer Disease
por: Contini, Cristina, et al.
Publicado: (2021)

Types I and V Anti-CRISPR Proteins: From Phage Defense to Eukaryotic Synthetic Gene Circuits
por: Yu, Lifang, et al.
Publicado: (2020)

Tandem mobilization of anti-phage defenses alongside SCCmec cassettes
por: Hossain, Motaher, et al.
Publicado: (2023)

The Influence of Copy-Number of Targeted Extrachromosomal Genetic Elements on the Outcome of CRISPR-Cas Defense
por: Severinov, Konstantin, et al.
Publicado: (2016)

Corrigendum: Top-Down Proteomics of Human Saliva Highlights Anti-inflammatory, Antioxidant, and Antimicrobial Defense Responses in Alzheimer Disease
por: Contini, Cristina, et al.
Publicado: (2021)

Function and Regulation of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) / CRISPR Associated (Cas) Systems
por: Richter, Corinna, et al.
Publicado: (2012)

Adhesions and Anti-Adhesion Systems Highlights
por: Torres-De La Roche, LA, et al.
Publicado: (2019)

CRISPR-Cas9 library screening approach for anti-cancer drug discovery: overview and perspectives
por: Chan, Yau-Tuen, et al.
Publicado: (2022)

Foreign DNA acquisition by the I-F CRISPR–Cas system requires all components of the interference machinery
por: Vorontsova, Daria, et al.
Publicado: (2015)

Anti‐CRISPRs: The natural inhibitors for CRISPR‐Cas systems
por: Zhang, Fei, et al.
Publicado: (2019)

Eosinophils and Anti-Pathogen Host Defense
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_4j1amadlkqbs1sl1m4dsd0tbg1