Cargando…

Combinational Pretreatment of Colony-Stimulating Factor 1 Receptor Inhibitor and Triptolide Upregulates BDNF-Akt and Autophagic Pathways to Improve Cerebral Ischemia

Ki20227, a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R), has been suggested to regulate microglia inflammatory function and neuronal synaptic plasticity. Triptolide (TP) pretreatment has neuroprotective effects through its anti-inflammatory and antiapoptotic features in ischem...

Descripción completa

Detalles Bibliográficos
Autores principales:	Du, Xiaoxue, Gao, Feng, Chen, Shijia, Botchway, Benson O. A., Amin, Nashwa, Hu, Zhiying, Fang, Marong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648715/ https://www.ncbi.nlm.nih.gov/pubmed/33192177 http://dx.doi.org/10.1155/2020/8796103

Ejemplares similares

Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia
por: Yang, Yang, et al.
Publicado: (2015)

Inhibition of Autophagy in Microglia Alters Depressive-Like Behavior via BDNF Pathway in Postpartum Depression
por: Tan, Xiaoning, et al.
Publicado: (2018)

Neuroprotective effects of DAHP and Triptolide in focal cerebral ischemia via apoptosis inhibition and PI3K/Akt/mTOR pathway activation
por: Li, Weiyun, et al.
Publicado: (2015)

Hypoxia Inducible Factor-1α Attenuates Ischemic Brain Damage by Modulating Inflammatory Response and Glial Activity
por: Amin, Nashwa, et al.
Publicado: (2021)

Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke
por: Du, Xiaoxue, et al.
Publicado: (2023)

Enhanced Glial Reaction and Altered Neuronal Nitric Oxide Synthase are Implicated in Attention Deficit Hyperactivity Disorder
por: Zhang, Peng, et al.
Publicado: (2022)

SIRT1 Protects Against Apoptosis by Promoting Autophagy in the Oxygen Glucose Deprivation/Reperfusion-Induced Injury
por: Ren, Qiannan, et al.
Publicado: (2019)

Inhibited CSF1R Alleviates Ischemia Injury via Inhibition of Microglia M1 Polarization and NLRP3 Pathway
por: Du, Xiaoxue, et al.
Publicado: (2020)

miR-16 and Fluoxetine Both Reverse Autophagic and Apoptotic Change in Chronic Unpredictable Mild Stress Model Rats
por: Yang, Yang, et al.
Publicado: (2017)

Agomelatine Softens Depressive-Like Behavior through the Regulation of Autophagy and Apoptosis
por: Chen, Fengpei, et al.
Publicado: (2021)

Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia
por: Qin, Yanhua, et al.
Publicado: (2018)

Biometals in Alzheimer disease: emerging therapeutic and diagnostic potential of molybdenum and iodine
por: Botchway, Benson O. A., et al.
Publicado: (2023)

Autophagic Upregulation Is Cytoprotective in Ischemia/Reperfusion-Injured Retina and Retinal Progenitor Cells
por: Tang, Larissa Ho Ching, et al.
Publicado: (2021)

Pretreatment with Sodium Phenylbutyrate Alleviates Cerebral Ischemia/Reperfusion Injury by Upregulating DJ-1 Protein
por: Yang, Rui-Xin, et al.
Publicado: (2017)

Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways
por: Liu, Xihong, et al.
Publicado: (2019)

Triptolide Attenuates Vascular Calcification by Upregulating Expression of miRNA-204
por: Pei, Yu-qiang, et al.
Publicado: (2021)

Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents
por: Botchway, Benson OA, et al.
Publicado: (2022)

Treadmill exercise ameliorates memory impairment through ERK-Akt-CREB-BDNF signaling pathway in cerebral ischemia gerbils
por: Lee, Su-Shin, et al.
Publicado: (2020)

Notoginsenoside R1 Improves Cerebral Ischemia/Reperfusion Injury by Promoting Neurogenesis via the BDNF/Akt/CREB Pathway
por: Zhu, Ting, et al.
Publicado: (2021)

ProBDNF Upregulation in Murine Hind Limb Ischemia Reperfusion Injury: A Driver of Inflammation
por: Aby, Katherine, et al.
Publicado: (2023)

Antagonist Effect of Triptolide on AKT Activation by Truncated Retinoid X Receptor-alpha
por: Lu, Na, et al.
Publicado: (2012)

Triptolide attenuates cerebral ischemia and reperfusion injury in rats through the inhibition the nuclear factor kappa B signaling pathway
por: Jin, Xiao-Qing, et al.
Publicado: (2015)

Neuroprotection by triptolide against cerebral ischemia/reperfusion injury through the inhibition of NF-κB/PUMA signal in rats
por: Zhang, Bin, et al.
Publicado: (2016)

Triptolide sensitizes cisplatin-resistant human epithelial ovarian cancer by inhibiting the phosphorylation of AKT
por: Huang, Genhua, et al.
Publicado: (2019)

Activation of Nrf2 Protects against Triptolide-Induced Hepatotoxicity
por: Li, Jia, et al.
Publicado: (2014)

Triptolide Upregulates Myocardial Forkhead Helix Transcription Factor p3 Expression and Attenuates Cardiac Hypertrophy
por: Ding, Yuan-Yuan, et al.
Publicado: (2016)

Triptolide inhibits proliferation, differentiation and induces apoptosis of osteoblastic MC3T3-E1 cells
por: Ji, Wei, et al.
Publicado: (2017)

Electroacupuncture Pretreatment against Cerebral Ischemia/Reperfusion Injury through Mitophagy
por: Mao, Chenlu, et al.
Publicado: (2020)

α‐tocopherol pretreatment alleviates cerebral ischemia‐reperfusion injury in rats
por: Lv, Shitao, et al.
Publicado: (2022)

Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin
por: Zhao, Hongxi, et al.
Publicado: (2012)

The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells
por: Hu, Xiao-Fan, et al.
Publicado: (2017)

Triptolide inhibits benign prostatic epithelium viability and migration and induces apoptosis via upregulation of microRNA-218
por: Yao, Changlei, et al.
Publicado: (2018)

DRAM is Involved in Hypoxia/Ischemia-Induced Autophagic Apoptosis in Hepatocytes
por: Xu, Jianji, et al.
Publicado: (2019)

Intravenous administration of DPSCs and BDNF improves neurological performance in rats with focal cerebral ischemia
por: Zhang, Xuemei, et al.
Publicado: (2018)

Electroacupuncture Pretreatment Mitigates Myocardial Ischemia/Reperfusion Injury via XBP1/GRP78/Akt Pathway
por: Wang, Nisha, et al.
Publicado: (2021)

Sevoflurane Preconditioning Confers Delayed Cardioprotection by Upregulating AMP-Activated Protein Kinase Levels to Restore Autophagic Flux in Ischemia-Reperfusion Rat Hearts
por: Hong, Lei, et al.
Publicado: (2020)

A review of the total syntheses of triptolide
por: Zhang, Xiang, et al.
Publicado: (2019)

Effects of puerarin on the pharmacokinetics of triptolide in rats
por: Wang, Qingfa, et al.
Publicado: (2019)

The molecular pathogenesis of triptolide-induced hepatotoxicity
por: Hu, Yeqing, et al.
Publicado: (2022)

Role of HIF-1a in regulating autophagic cell survival during cerebral ischemia reperfusion in rats
por: Guo, Yongqing
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7k7ob6oj4m749prr6cv8sol60s