Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly

Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM interactions mediate heterodimerization of the constitutive splicing factors U2AF65 and U2AF35 and between other splicing factors th...

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Detalles Bibliográficos
Autores principales: Jagtap, Pravin Kumar Ankush, Kubelka, Tomáš, Soni, Komal, Will, Cindy L., Garg, Divita, Sippel, Claudia, Kapp, Tobias G., Potukuchi, Harish Kumar, Schorpp, Kenji, Hadian, Kamyar, Kessler, Horst, Lührmann, Reinhard, Hausch, Felix, Bach, Thorsten, Sattler, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7648758/
https://www.ncbi.nlm.nih.gov/pubmed/33159082
http://dx.doi.org/10.1038/s41467-020-19514-1

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