Improving reproducibility in animal research

There have been increasingly lively discussions about many published scientific results failing validation by independent studies. This so-called reproducibility crisis has led to particularly strong criticism of methodological weaknesses in animal research. Inappropriate statistical methods, poor experimental design, and extreme standardization in trial design are some contributing factors to the problem. The purpose of this Collection is to present original methodologies to improve the status quo and additionally to report meta-research about the reproducibility of published animal research.