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Validation of a semiautomated volumetric approach for fetal neurosonography using 5DCNS+ in clinical data from > 1100 consecutive pregnancies

OBJECTIVE: The aim of this study was to evaluate the validity of a semiautomated volumetric approach (5DCNS+) for the detailed assessment of the fetal brain in a clinical setting. METHODS: Stored 3D volumes of > 1100 consecutive 2nd and 3rd trimester pregnancies (range 15–36 gestational weeks) we...

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Autores principales: Welp, Amrei, Gembicki, Michael, Rody, Achim, Weichert, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649164/
https://www.ncbi.nlm.nih.gov/pubmed/32350601
http://dx.doi.org/10.1007/s00381-020-04607-5
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author Welp, Amrei
Gembicki, Michael
Rody, Achim
Weichert, Jan
author_facet Welp, Amrei
Gembicki, Michael
Rody, Achim
Weichert, Jan
author_sort Welp, Amrei
collection PubMed
description OBJECTIVE: The aim of this study was to evaluate the validity of a semiautomated volumetric approach (5DCNS+) for the detailed assessment of the fetal brain in a clinical setting. METHODS: Stored 3D volumes of > 1100 consecutive 2nd and 3rd trimester pregnancies (range 15–36 gestational weeks) were analyzed using a workflow-based volumetric approach 5DCNS+, enabling semiautomated reconstruction of diagnostic planes of the fetal central nervous system (CNS). All 3D data sets were examined for plane accuracy, the need for manual adjustment, and fetal-maternal characteristics affecting successful plane reconstruction. We also examined the potential of these standardized views to give additional information on proper gyration and sulci formation with advancing gestation. RESULTS: Based on our data, we were able to show that gestational age with an OR of 1.085 (95% CI 1.041–1.132) and maternal BMI with an OR of 1.022 (95% CI 1.041–1.054) only had a slight impact on the number of manual adjustments needed to reconstruct the complete volume, while maternal age and fetal position during acquisition (p = 0.260) did not have a significant effect. For the vast majority (958/1019; 94%) of volumes, using 5DCNS+ resulted in proper reconstruction of all nine diagnostic planes. In less than 1% (89/9171 planes) of volumes, the program failed to give sufficient information. 5DCNS+ was able to show the onset and changing appearance of CNS folding in a detailed and timely manner (lateral/parietooccipital sulcus formation seen in < 65% at 16–17 gestational weeks vs. 94.6% at 19 weeks). CONCLUSIONS: The 5DCNS+ method provides a reliable algorithm to produce detailed, 3D volume–based assessments of fetal CNS integrity through a standardized reconstruction of the orthogonal diagnostic planes. The method further gives valid and reproducible information regarding ongoing cortical development retrieved from these volume sets that might aid in earlier in utero recognition of subtle structural CNS anomalies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00381-020-04607-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-76491642020-11-10 Validation of a semiautomated volumetric approach for fetal neurosonography using 5DCNS+ in clinical data from > 1100 consecutive pregnancies Welp, Amrei Gembicki, Michael Rody, Achim Weichert, Jan Childs Nerv Syst Original Article OBJECTIVE: The aim of this study was to evaluate the validity of a semiautomated volumetric approach (5DCNS+) for the detailed assessment of the fetal brain in a clinical setting. METHODS: Stored 3D volumes of > 1100 consecutive 2nd and 3rd trimester pregnancies (range 15–36 gestational weeks) were analyzed using a workflow-based volumetric approach 5DCNS+, enabling semiautomated reconstruction of diagnostic planes of the fetal central nervous system (CNS). All 3D data sets were examined for plane accuracy, the need for manual adjustment, and fetal-maternal characteristics affecting successful plane reconstruction. We also examined the potential of these standardized views to give additional information on proper gyration and sulci formation with advancing gestation. RESULTS: Based on our data, we were able to show that gestational age with an OR of 1.085 (95% CI 1.041–1.132) and maternal BMI with an OR of 1.022 (95% CI 1.041–1.054) only had a slight impact on the number of manual adjustments needed to reconstruct the complete volume, while maternal age and fetal position during acquisition (p = 0.260) did not have a significant effect. For the vast majority (958/1019; 94%) of volumes, using 5DCNS+ resulted in proper reconstruction of all nine diagnostic planes. In less than 1% (89/9171 planes) of volumes, the program failed to give sufficient information. 5DCNS+ was able to show the onset and changing appearance of CNS folding in a detailed and timely manner (lateral/parietooccipital sulcus formation seen in < 65% at 16–17 gestational weeks vs. 94.6% at 19 weeks). CONCLUSIONS: The 5DCNS+ method provides a reliable algorithm to produce detailed, 3D volume–based assessments of fetal CNS integrity through a standardized reconstruction of the orthogonal diagnostic planes. The method further gives valid and reproducible information regarding ongoing cortical development retrieved from these volume sets that might aid in earlier in utero recognition of subtle structural CNS anomalies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00381-020-04607-5) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-04-30 2020 /pmc/articles/PMC7649164/ /pubmed/32350601 http://dx.doi.org/10.1007/s00381-020-04607-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Welp, Amrei
Gembicki, Michael
Rody, Achim
Weichert, Jan
Validation of a semiautomated volumetric approach for fetal neurosonography using 5DCNS+ in clinical data from > 1100 consecutive pregnancies
title Validation of a semiautomated volumetric approach for fetal neurosonography using 5DCNS+ in clinical data from > 1100 consecutive pregnancies
title_full Validation of a semiautomated volumetric approach for fetal neurosonography using 5DCNS+ in clinical data from > 1100 consecutive pregnancies
title_fullStr Validation of a semiautomated volumetric approach for fetal neurosonography using 5DCNS+ in clinical data from > 1100 consecutive pregnancies
title_full_unstemmed Validation of a semiautomated volumetric approach for fetal neurosonography using 5DCNS+ in clinical data from > 1100 consecutive pregnancies
title_short Validation of a semiautomated volumetric approach for fetal neurosonography using 5DCNS+ in clinical data from > 1100 consecutive pregnancies
title_sort validation of a semiautomated volumetric approach for fetal neurosonography using 5dcns+ in clinical data from > 1100 consecutive pregnancies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649164/
https://www.ncbi.nlm.nih.gov/pubmed/32350601
http://dx.doi.org/10.1007/s00381-020-04607-5
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