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Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis
INTRODUCTION: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease characterized by eczema and pruritus, and frequently impairs sleep quality. Although cyclosporine improves symptoms of AD, objective evaluation of sleep in patients with AD treated with cyclosporine has not been...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649172/ https://www.ncbi.nlm.nih.gov/pubmed/32975744 http://dx.doi.org/10.1007/s13555-020-00451-2 |
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author | Yasuda, Ken-ichi Ishiuji, Yozo Endo, Takuro Tanito, Katsumi Kamide, Ryoichi Nobeyama, Yoshimasa Asahina, Akihiko |
author_facet | Yasuda, Ken-ichi Ishiuji, Yozo Endo, Takuro Tanito, Katsumi Kamide, Ryoichi Nobeyama, Yoshimasa Asahina, Akihiko |
author_sort | Yasuda, Ken-ichi |
collection | PubMed |
description | INTRODUCTION: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease characterized by eczema and pruritus, and frequently impairs sleep quality. Although cyclosporine improves symptoms of AD, objective evaluation of sleep in patients with AD treated with cyclosporine has not been reported. This study was conducted to elucidate the effects of cyclosporine on sleep quality for patients with AD. METHODS: Twelve patients with moderate-to-severe AD were recruited. Nocturnal sleep quality was evaluated for 7 days using a sleep analyzer, which patients wore at the waist before and after cyclosporine was administered at 2.0–4.0 mg/kg per day. Seven parameters of sleep quality were measured before and after cyclosporine administration for a period of 7 days for each patient. RESULTS: The administration of cyclosporine significantly improved total sleep time in four cases, sleep latency in two cases, wake after sleep onset in six cases, number of awakenings in two cases, sleep efficiency in seven cases, number of awakenings for more than 8 min in three cases, and number of position changes recorded every 2 min in three cases. The mean values of sleep latency significantly decreased after cyclosporine administration (P = 0.023). The mean value of sleep efficiency significantly increased after the administration (P = 0.002). CONCLUSION: Cyclosporine improves sleep quality in patients with moderate-to-severe AD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13555-020-00451-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7649172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-76491722020-11-10 Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis Yasuda, Ken-ichi Ishiuji, Yozo Endo, Takuro Tanito, Katsumi Kamide, Ryoichi Nobeyama, Yoshimasa Asahina, Akihiko Dermatol Ther (Heidelb) Original Research INTRODUCTION: Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease characterized by eczema and pruritus, and frequently impairs sleep quality. Although cyclosporine improves symptoms of AD, objective evaluation of sleep in patients with AD treated with cyclosporine has not been reported. This study was conducted to elucidate the effects of cyclosporine on sleep quality for patients with AD. METHODS: Twelve patients with moderate-to-severe AD were recruited. Nocturnal sleep quality was evaluated for 7 days using a sleep analyzer, which patients wore at the waist before and after cyclosporine was administered at 2.0–4.0 mg/kg per day. Seven parameters of sleep quality were measured before and after cyclosporine administration for a period of 7 days for each patient. RESULTS: The administration of cyclosporine significantly improved total sleep time in four cases, sleep latency in two cases, wake after sleep onset in six cases, number of awakenings in two cases, sleep efficiency in seven cases, number of awakenings for more than 8 min in three cases, and number of position changes recorded every 2 min in three cases. The mean values of sleep latency significantly decreased after cyclosporine administration (P = 0.023). The mean value of sleep efficiency significantly increased after the administration (P = 0.002). CONCLUSION: Cyclosporine improves sleep quality in patients with moderate-to-severe AD. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13555-020-00451-2) contains supplementary material, which is available to authorized users. Springer Healthcare 2020-09-25 /pmc/articles/PMC7649172/ /pubmed/32975744 http://dx.doi.org/10.1007/s13555-020-00451-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Original Research Yasuda, Ken-ichi Ishiuji, Yozo Endo, Takuro Tanito, Katsumi Kamide, Ryoichi Nobeyama, Yoshimasa Asahina, Akihiko Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis |
title | Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis |
title_full | Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis |
title_fullStr | Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis |
title_full_unstemmed | Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis |
title_short | Cyclosporine Improves Sleep Quality in Patients with Atopic Dermatitis |
title_sort | cyclosporine improves sleep quality in patients with atopic dermatitis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649172/ https://www.ncbi.nlm.nih.gov/pubmed/32975744 http://dx.doi.org/10.1007/s13555-020-00451-2 |
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