Excitotoxicity: Still Hammering the Ischemic Brain in 2020

Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate (NMDA) antagonists in high profile clinical stroke trials. Nonetheless there has been steady progress in elucidating un...

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Detalles Bibliográficos
Autor principal: Choi, Dennis W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649323/
https://www.ncbi.nlm.nih.gov/pubmed/33192266
http://dx.doi.org/10.3389/fnins.2020.579953
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author Choi, Dennis W.
author_facet Choi, Dennis W.
author_sort Choi, Dennis W.
collection PubMed
description Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate (NMDA) antagonists in high profile clinical stroke trials. Nonetheless there has been steady progress in elucidating underlying mechanisms. This review will outline the historical path to current understandings of excitotoxicity in the ischemic brain, and suggest that this knowledge should be leveraged now to develop neuroprotective treatments for stroke.
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spelling pubmed-76493232020-11-13 Excitotoxicity: Still Hammering the Ischemic Brain in 2020 Choi, Dennis W. Front Neurosci Neuroscience Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate (NMDA) antagonists in high profile clinical stroke trials. Nonetheless there has been steady progress in elucidating underlying mechanisms. This review will outline the historical path to current understandings of excitotoxicity in the ischemic brain, and suggest that this knowledge should be leveraged now to develop neuroprotective treatments for stroke. Frontiers Media S.A. 2020-10-26 /pmc/articles/PMC7649323/ /pubmed/33192266 http://dx.doi.org/10.3389/fnins.2020.579953 Text en Copyright © 2020 Choi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Choi, Dennis W.
Excitotoxicity: Still Hammering the Ischemic Brain in 2020
title Excitotoxicity: Still Hammering the Ischemic Brain in 2020
title_full Excitotoxicity: Still Hammering the Ischemic Brain in 2020
title_fullStr Excitotoxicity: Still Hammering the Ischemic Brain in 2020
title_full_unstemmed Excitotoxicity: Still Hammering the Ischemic Brain in 2020
title_short Excitotoxicity: Still Hammering the Ischemic Brain in 2020
title_sort excitotoxicity: still hammering the ischemic brain in 2020
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649323/
https://www.ncbi.nlm.nih.gov/pubmed/33192266
http://dx.doi.org/10.3389/fnins.2020.579953
work_keys_str_mv AT choidennisw excitotoxicitystillhammeringtheischemicbrainin2020

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