An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

A growing number of epigenome-wide association studies have demonstrated a role for DNA methylation in the brain in Alzheimer's disease. With the aim of exploring peripheral biomarker potential, we have examined DNA methylation patterns in whole blood collected from 284 individuals in the AddNe...

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Detalles Bibliográficos
Autores principales: Roubroeks, Janou A.Y., Smith, Adam R., Smith, Rebecca G., Pishva, Ehsan, Ibrahim, Zina, Sattlecker, Martina, Hannon, Eilis J., Kłoszewska, Iwona, Mecocci, Patrizia, Soininen, Hilkka, Tsolaki, Magda, Vellas, Bruno, Wahlund, Lars-Olof, Aarsland, Dag, Proitsi, Petroula, Hodges, Angela, Lovestone, Simon, Newhouse, Stephen J., Dobson, Richard J.B., Mill, Jonathan, van den Hove, Daniël L.A., Lunnon, Katie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649340/
https://www.ncbi.nlm.nih.gov/pubmed/32745807
http://dx.doi.org/10.1016/j.neurobiolaging.2020.06.023

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