Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies

HIV-1 envelope (Env) N-glycosylation impact virus-cell entry and immune evasion. How each glycan interacts to shape the Env-protein-sugar complex and affects Env function is not well understood. Here, analysis of two Env variants from the same donor, with differing functional characteristics and N-g...

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Detalles Bibliográficos
Autores principales: Wei, Qing, Hargett, Audra A., Knoppova, Barbora, Duverger, Alexandra, Rawi, Reda, Shen, Chen-Hsiang, Farney, S. Katie, Hall, Stacy, Brown, Rhubell, Keele, Brandon F., Heath, Sonya L., Saag, Michael S., Kutsch, Olaf, Chuang, Gwo-Yu, Kwong, Peter D., Moldoveanu, Zina, Raska, Milan, Renfrow, Matthew B., Novak, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649354/
https://www.ncbi.nlm.nih.gov/pubmed/33205023
http://dx.doi.org/10.1016/j.isci.2020.101711

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