Cargando…
Multifaceted Actions of GFI1 and GFI1B in Hematopoietic Stem Cell Self-Renewal and Lineage Commitment
Growth factor independence 1 (GFI1) and the closely related protein GFI1B are small nuclear proteins that act as DNA binding transcriptional repressors. Both recognize the same consensus DNA binding motif via their C-terminal zinc finger domains and regulate the expression of their target genes by r...
Autores principales: | Beauchemin, Hugues, Möröy, Tarik |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649360/ https://www.ncbi.nlm.nih.gov/pubmed/33193732 http://dx.doi.org/10.3389/fgene.2020.591099 |
Ejemplares similares
-
Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b
por: Vassen, Lothar, et al.
Publicado: (2005) -
Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes
por: Shooshtarizadeh, Peiman, et al.
Publicado: (2019) -
Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes
por: Beauchemin, Hugues, et al.
Publicado: (2017) -
Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
por: Fraszczak, Jennifer, et al.
Publicado: (2018) -
Gfi1 as a regulator of p53 and a therapeutic target for ALL
por: Khandanpour, Cyrus, et al.
Publicado: (2013)