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Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report

BACKGROUND : Celiac disease is a digestive inflammatory syndrome with several complications. It is associated with coagulation and platelets abnormalities leading to thromboembolic events. Cerebral venous thrombosis is an exceptional localization of thrombosis in celiac disease and could be life-thr...

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Autores principales: Bouziane, Maha, Arous, Salim, Habbal, Rachida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649450/
https://www.ncbi.nlm.nih.gov/pubmed/33204951
http://dx.doi.org/10.1093/ehjcr/ytaa200
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author Bouziane, Maha
Arous, Salim
Habbal, Rachida
author_facet Bouziane, Maha
Arous, Salim
Habbal, Rachida
author_sort Bouziane, Maha
collection PubMed
description BACKGROUND : Celiac disease is a digestive inflammatory syndrome with several complications. It is associated with coagulation and platelets abnormalities leading to thromboembolic events. Cerebral venous thrombosis is an exceptional localization of thrombosis in celiac disease and could be life-threatening. CASE SUMMARY : A 17-year-old female patient with history of celiac disease and not following a gluten-free diet, checked in to the emergency department for a sudden, 2-week-old, and deteriorating, onset of intense headache and muscle weakness. The cerebral computed tomography-scan showed bilateral fronto-parietal hypodensity with micro-bleeds. We investigated using a cerebral magnetic resonance imaging that revealed superior longitudinal sinus thrombosis and right transverse and sigmoid sinuses thrombosis, along with right haematoma and ischaemic areas. The patient was prescribed anticoagulation therapy. Follow-ups over a 2-year period confirmed a favourable outcome and a complete regression of symptoms. DISCUSSION : Evolution of celiac disease could be associated with several complications. Eighty-five percent of patients is potentially exposed to thromboembolic events due to the hypercoagulability state of the disease and different coagulation and fibrinolysis abnormalities (e.g. hyperhomocysteinaemia, protein C and S deficiencies, vitamin K and B deficiencies). Cerebral venous thrombosis is a rare thromboembolic localization. Anticoagulation is efficient in most cases though endovascular treatment might be required.
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spelling pubmed-76494502020-11-16 Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report Bouziane, Maha Arous, Salim Habbal, Rachida Eur Heart J Case Rep Case Reports BACKGROUND : Celiac disease is a digestive inflammatory syndrome with several complications. It is associated with coagulation and platelets abnormalities leading to thromboembolic events. Cerebral venous thrombosis is an exceptional localization of thrombosis in celiac disease and could be life-threatening. CASE SUMMARY : A 17-year-old female patient with history of celiac disease and not following a gluten-free diet, checked in to the emergency department for a sudden, 2-week-old, and deteriorating, onset of intense headache and muscle weakness. The cerebral computed tomography-scan showed bilateral fronto-parietal hypodensity with micro-bleeds. We investigated using a cerebral magnetic resonance imaging that revealed superior longitudinal sinus thrombosis and right transverse and sigmoid sinuses thrombosis, along with right haematoma and ischaemic areas. The patient was prescribed anticoagulation therapy. Follow-ups over a 2-year period confirmed a favourable outcome and a complete regression of symptoms. DISCUSSION : Evolution of celiac disease could be associated with several complications. Eighty-five percent of patients is potentially exposed to thromboembolic events due to the hypercoagulability state of the disease and different coagulation and fibrinolysis abnormalities (e.g. hyperhomocysteinaemia, protein C and S deficiencies, vitamin K and B deficiencies). Cerebral venous thrombosis is a rare thromboembolic localization. Anticoagulation is efficient in most cases though endovascular treatment might be required. Oxford University Press 2020-08-23 /pmc/articles/PMC7649450/ /pubmed/33204951 http://dx.doi.org/10.1093/ehjcr/ytaa200 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Reports
Bouziane, Maha
Arous, Salim
Habbal, Rachida
Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report
title Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report
title_full Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report
title_fullStr Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report
title_full_unstemmed Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report
title_short Cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report
title_sort cerebral venous thrombosis as a rare thromboembolic complication of celiac disease: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649450/
https://www.ncbi.nlm.nih.gov/pubmed/33204951
http://dx.doi.org/10.1093/ehjcr/ytaa200
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AT habbalrachida cerebralvenousthrombosisasararethromboemboliccomplicationofceliacdiseaseacasereport