Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU

We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected wit...

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Autores principales: Jing, Hongwu, Ackerman, William E., Zhao, Guomao, El Helou, Yara, Buhimschi, Catalin S., Buhimschi, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649632/
https://www.ncbi.nlm.nih.gov/pubmed/33197855
http://dx.doi.org/10.1016/j.placenta.2020.11.001
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author Jing, Hongwu
Ackerman, William E.
Zhao, Guomao
El Helou, Yara
Buhimschi, Catalin S.
Buhimschi, Irina A.
author_facet Jing, Hongwu
Ackerman, William E.
Zhao, Guomao
El Helou, Yara
Buhimschi, Catalin S.
Buhimschi, Irina A.
author_sort Jing, Hongwu
collection PubMed
description We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection. Common proteins included the SARS-CoV-2 entry receptor ACE2 and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus to escape host immunity. Remarkably, placental ENDOU mRNA expression far exceeded that of ACE2. Immunohistochemistry confirmed ENDOU localization at the hemochorial maternal-fetal interface. Investigation of ENDOU's relevance to vertical transmission of SARS-CoV-2 is further warranted.
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spelling pubmed-76496322020-11-09 Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU Jing, Hongwu Ackerman, William E. Zhao, Guomao El Helou, Yara Buhimschi, Catalin S. Buhimschi, Irina A. Placenta Article We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection. Common proteins included the SARS-CoV-2 entry receptor ACE2 and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus to escape host immunity. Remarkably, placental ENDOU mRNA expression far exceeded that of ACE2. Immunohistochemistry confirmed ENDOU localization at the hemochorial maternal-fetal interface. Investigation of ENDOU's relevance to vertical transmission of SARS-CoV-2 is further warranted. Elsevier Ltd. 2021-01-15 2020-11-09 /pmc/articles/PMC7649632/ /pubmed/33197855 http://dx.doi.org/10.1016/j.placenta.2020.11.001 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Jing, Hongwu
Ackerman, William E.
Zhao, Guomao
El Helou, Yara
Buhimschi, Catalin S.
Buhimschi, Irina A.
Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU
title Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU
title_full Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU
title_fullStr Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU
title_full_unstemmed Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU
title_short Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis – Potential roles of placental ACE2 and ENDOU
title_sort connecting the dots on vertical transmission of sars-cov-2 using protein-protein interaction network analysis – potential roles of placental ace2 and endou
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649632/
https://www.ncbi.nlm.nih.gov/pubmed/33197855
http://dx.doi.org/10.1016/j.placenta.2020.11.001
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