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Sex and COVID-19: A Protective Role for Reproductive Steroids

Evidence shows coronavirus disease 2019 (COVID-19)-induced symptom severity and mortality is more frequent in men than in women, suggesting sex steroids may play a protective role. Female reproductive steroids, estrogen and progesterone, and its metabolite allopregnanolone, are anti-inflammatory, re...

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Detalles Bibliográficos
Autor principal: Pinna, Graziano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649655/
https://www.ncbi.nlm.nih.gov/pubmed/33229187
http://dx.doi.org/10.1016/j.tem.2020.11.004
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author Pinna, Graziano
author_facet Pinna, Graziano
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description Evidence shows coronavirus disease 2019 (COVID-19)-induced symptom severity and mortality is more frequent in men than in women, suggesting sex steroids may play a protective role. Female reproductive steroids, estrogen and progesterone, and its metabolite allopregnanolone, are anti-inflammatory, reshape competence of immune cells, stimulate antibody production, and promote proliferation and repair of respiratory epithelial cells, suggesting they may protect against COVID-19 symptoms.
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spelling pubmed-76496552020-11-09 Sex and COVID-19: A Protective Role for Reproductive Steroids Pinna, Graziano Trends Endocrinol Metab Science & Society Evidence shows coronavirus disease 2019 (COVID-19)-induced symptom severity and mortality is more frequent in men than in women, suggesting sex steroids may play a protective role. Female reproductive steroids, estrogen and progesterone, and its metabolite allopregnanolone, are anti-inflammatory, reshape competence of immune cells, stimulate antibody production, and promote proliferation and repair of respiratory epithelial cells, suggesting they may protect against COVID-19 symptoms. Elsevier Ltd. 2021-01 2020-11-09 /pmc/articles/PMC7649655/ /pubmed/33229187 http://dx.doi.org/10.1016/j.tem.2020.11.004 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Science & Society
Pinna, Graziano
Sex and COVID-19: A Protective Role for Reproductive Steroids
title Sex and COVID-19: A Protective Role for Reproductive Steroids
title_full Sex and COVID-19: A Protective Role for Reproductive Steroids
title_fullStr Sex and COVID-19: A Protective Role for Reproductive Steroids
title_full_unstemmed Sex and COVID-19: A Protective Role for Reproductive Steroids
title_short Sex and COVID-19: A Protective Role for Reproductive Steroids
title_sort sex and covid-19: a protective role for reproductive steroids
topic Science & Society
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649655/
https://www.ncbi.nlm.nih.gov/pubmed/33229187
http://dx.doi.org/10.1016/j.tem.2020.11.004
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