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Sex and COVID-19: A Protective Role for Reproductive Steroids
Evidence shows coronavirus disease 2019 (COVID-19)-induced symptom severity and mortality is more frequent in men than in women, suggesting sex steroids may play a protective role. Female reproductive steroids, estrogen and progesterone, and its metabolite allopregnanolone, are anti-inflammatory, re...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649655/ https://www.ncbi.nlm.nih.gov/pubmed/33229187 http://dx.doi.org/10.1016/j.tem.2020.11.004 |
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author | Pinna, Graziano |
author_facet | Pinna, Graziano |
author_sort | Pinna, Graziano |
collection | PubMed |
description | Evidence shows coronavirus disease 2019 (COVID-19)-induced symptom severity and mortality is more frequent in men than in women, suggesting sex steroids may play a protective role. Female reproductive steroids, estrogen and progesterone, and its metabolite allopregnanolone, are anti-inflammatory, reshape competence of immune cells, stimulate antibody production, and promote proliferation and repair of respiratory epithelial cells, suggesting they may protect against COVID-19 symptoms. |
format | Online Article Text |
id | pubmed-7649655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76496552020-11-09 Sex and COVID-19: A Protective Role for Reproductive Steroids Pinna, Graziano Trends Endocrinol Metab Science & Society Evidence shows coronavirus disease 2019 (COVID-19)-induced symptom severity and mortality is more frequent in men than in women, suggesting sex steroids may play a protective role. Female reproductive steroids, estrogen and progesterone, and its metabolite allopregnanolone, are anti-inflammatory, reshape competence of immune cells, stimulate antibody production, and promote proliferation and repair of respiratory epithelial cells, suggesting they may protect against COVID-19 symptoms. Elsevier Ltd. 2021-01 2020-11-09 /pmc/articles/PMC7649655/ /pubmed/33229187 http://dx.doi.org/10.1016/j.tem.2020.11.004 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Science & Society Pinna, Graziano Sex and COVID-19: A Protective Role for Reproductive Steroids |
title | Sex and COVID-19: A Protective Role for Reproductive Steroids |
title_full | Sex and COVID-19: A Protective Role for Reproductive Steroids |
title_fullStr | Sex and COVID-19: A Protective Role for Reproductive Steroids |
title_full_unstemmed | Sex and COVID-19: A Protective Role for Reproductive Steroids |
title_short | Sex and COVID-19: A Protective Role for Reproductive Steroids |
title_sort | sex and covid-19: a protective role for reproductive steroids |
topic | Science & Society |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649655/ https://www.ncbi.nlm.nih.gov/pubmed/33229187 http://dx.doi.org/10.1016/j.tem.2020.11.004 |
work_keys_str_mv | AT pinnagraziano sexandcovid19aprotectiveroleforreproductivesteroids |