Pharmacogenetics of TNF inhibitor response in rheumatoid arthritis utilizing the two-component disease activity score

AIM: TNF inhibitor drugs are a treatment option for rheumatoid arthritis, but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 s...

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Detalles Bibliográficos
Autores principales: Gilani, Syed SA, Nair, Nisha, Plant, Darren, Hyrich, Kimme, Morgan, Ann W, Morris, Andrew P, Wilson, Anthony G, Isaacs, John D, Barton, Anne, Bluett, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649675/
https://www.ncbi.nlm.nih.gov/pubmed/33124499
http://dx.doi.org/10.2217/pgs-2020-0043
Descripción
Sumario:AIM: TNF inhibitor drugs are a treatment option for rheumatoid arthritis, but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 score to determine whether SNPs associated with response were replicated in the UK population. MATERIALS & METHODS: A literature review identified TNF inhibitor response SNPs. Linear regression was conducted to replicate associations with 4C or 2C-DAS28 response. RESULTS: Eighteen independent SNPs were analyzed in 1828 patients. One and four associations with 4C and 2C-DAS28 response respectively were identified (p ≤ 0.05). CONCLUSION: Further genetic associations were replicated using the 2C-DAS28 which may reflect the objective nature of 2C-AS28.

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