Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused pooled RNAi screen and confirm the finding by using a geneticall...

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Detalles Bibliográficos
Autores principales: Maitituoheti, Mayinuer, Keung, Emily Z., Tang, Ming, Yan, Liang, Alam, Hunain, Han, Guangchun, Singh, Anand K., Raman, Ayush T., Terranova, Christopher, Sarkar, Sharmistha, Orouji, Elias, Amin, Samir B., Sharma, Sneha, Williams, Maura, Samant, Neha S., Dhamdhere, Mayura, Zheng, Norman, Shah, Tara, Shah, Amiksha, Axelrad, Jacob B., Anvar, Nazanin E., Lin, Yu-Hsi, Jiang, Shan, Chang, Edward Q., Ingram, Davis R., Wang, Wei-Lien, Lazar, Alexander, Lee, Min Gyu, Muller, Florian, Wang, Linghua, Ying, Haoqiang, Rai, Kunal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649750/
https://www.ncbi.nlm.nih.gov/pubmed/33086062
http://dx.doi.org/10.1016/j.celrep.2020.108293

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