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G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization
Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens. Here, we demonstrate an unidentified role of GPER as...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649801/ https://www.ncbi.nlm.nih.gov/pubmed/33195261 http://dx.doi.org/10.3389/fcell.2020.592628 |
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author | Lachowski, Dariusz Cortes, Ernesto Matellan, Carlos Rice, Alistair Lee, David A. Thorpe, Stephen D. del Río Hernández, Armando E. |
author_facet | Lachowski, Dariusz Cortes, Ernesto Matellan, Carlos Rice, Alistair Lee, David A. Thorpe, Stephen D. del Río Hernández, Armando E. |
author_sort | Lachowski, Dariusz |
collection | PubMed |
description | Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens. Here, we demonstrate an unidentified role of GPER as a cellular mechanoregulator. G protein-coupled estrogen receptor signaling controls the assembly of stress fibers, the dynamics of the associated focal adhesions, and cell polarization via RhoA GTPase (RhoA). G protein-coupled estrogen receptor activation inhibits F-actin polymerization and subsequently triggers a negative feedback that transcriptionally suppresses the expression of monomeric G-actin. Given the broad expression of GPER and the range of cytoskeletal changes modulated by this receptor, our findings position GPER as a key player in mechanotransduction. |
format | Online Article Text |
id | pubmed-7649801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76498012020-11-13 G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization Lachowski, Dariusz Cortes, Ernesto Matellan, Carlos Rice, Alistair Lee, David A. Thorpe, Stephen D. del Río Hernández, Armando E. Front Cell Dev Biol Cell and Developmental Biology Mechanical forces regulate cell functions through multiple pathways. G protein-coupled estrogen receptor (GPER) is a seven-transmembrane receptor that is ubiquitously expressed across tissues and mediates the acute cellular response to estrogens. Here, we demonstrate an unidentified role of GPER as a cellular mechanoregulator. G protein-coupled estrogen receptor signaling controls the assembly of stress fibers, the dynamics of the associated focal adhesions, and cell polarization via RhoA GTPase (RhoA). G protein-coupled estrogen receptor activation inhibits F-actin polymerization and subsequently triggers a negative feedback that transcriptionally suppresses the expression of monomeric G-actin. Given the broad expression of GPER and the range of cytoskeletal changes modulated by this receptor, our findings position GPER as a key player in mechanotransduction. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7649801/ /pubmed/33195261 http://dx.doi.org/10.3389/fcell.2020.592628 Text en Copyright © 2020 Lachowski, Cortes, Matellan, Rice, Lee, Thorpe and del Río Hernández. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Lachowski, Dariusz Cortes, Ernesto Matellan, Carlos Rice, Alistair Lee, David A. Thorpe, Stephen D. del Río Hernández, Armando E. G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization |
title | G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization |
title_full | G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization |
title_fullStr | G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization |
title_full_unstemmed | G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization |
title_short | G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization |
title_sort | g protein-coupled estrogen receptor regulates actin cytoskeleton dynamics to impair cell polarization |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649801/ https://www.ncbi.nlm.nih.gov/pubmed/33195261 http://dx.doi.org/10.3389/fcell.2020.592628 |
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