A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix–Loop–Helix Transcription Factor

[Image: see text] We report a conformational switch between two distinct intrinsically disordered subensembles within the active site of a transcription factor. This switch highlights an evolutionary benefit conferred by the high plasticity of intrinsically disordered domains, namely, their potentia...

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Detalles Bibliográficos
Autores principales: Sicoli, Giuseppe, Kress, Thomas, Vezin, Hervé, Ledolter, Karin, Kurzbach, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649839/
https://www.ncbi.nlm.nih.gov/pubmed/33030907
http://dx.doi.org/10.1021/acs.jpclett.0c02242

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